Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.67 |
| ▸ | HTT | P42858 | 10/20 | 0.67 |
| ▸ | RAB9A | P51151 | 9/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 8/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.67 |
| ▸ | NPC1 | O15118 | 6/20 | 0.67 |
| ▸ | MEN1 | O00255 | 6/20 | 0.67 |
| ▸ | ATM | Q13315 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | MITF | O75030 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | XBP1 | P17861 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | CDC25A | P30304 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.55 |
| ▸ | CDC25B | P30305 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8663288 | 0.85 | MAPT (0.74) | MAPTHTTRAB9ANPSR1KMT2A | |
| SCHEMBL29633261 | 0.80 | MAPT (1.00) | MAPTHTTRAB9ANPSR1KMT2A | |
| SCHEMBL6506683 | 0.80 | MAPT (1.00) | MAPTHTTRAB9ANPSR1KMT2A | |
| SCHEMBL1243522 | 0.80 | MAPT (0.73) | MAPTHTTRAB9ANPSR1KMT2A | |
| SCHEMBL32664539 | 0.77 | MAPT (0.79) | MAPTHTTRAB9ANPSR1KMT2A | |
| SCHEMBL4873496 | 0.75 | MAPT (1.00) | MAPTHTTRAB9ANPSR1KMT2A | |
| SCHEMBL7240445 | 0.75 | MAPT (0.74) | MAPTHTTRAB9ANPSR1KMT2A | |
| SCHEMBL4868219 | 0.75 | MAPT (1.00) | MAPTHTTRAB9ANPSR1KMT2A | |
| SCHEMBL5808588 | 0.74 | MAPT (0.68) | MAPTHTTRAB9ANPSR1KMT2A | |
| SCHEMBL12283300 | 0.74 | MAPT (0.58) | MAPTHTTRAB9ANPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472315-B2 | Inhibitors of methionine aminopeptidases and methods of treating disorders | THE JOHNS HOPKINS UNIVERSITY (US) | 2019-11-12 | — | — | US | disclosed |
| US-20120196852-A1 | INHIBITORS OF METHIONINE AMINOPEPTIDASES AND METHODS OF TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-08-02 | — | — | US | disclosed |
| WO-2011017519-A2 | INHIBITORS OF METHIONINE AMINOPEPTIDASES AND METHODS OF TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196852-A1 | INHIBITORS OF METHIONINE AMINOPEPTIDASES AND METHODS OF TREATING DISORDERS | METAP1, METAP2, ENPEP | MAPT 1551/4885HTT 784/4885RAB9A 1980/4885 |
| US-10472315-B2 | Inhibitors of methionine aminopeptidases and methods of treating disorders | METAP1, METAP2, ENPEP | MAPT 1551/4885HTT 784/4885RAB9A 1980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.