SCHEMBL12424934

SCHEMBL12424934

COc1cc(C2=C3C(=O)NC(c4cc(Cl)c(OC)c(OC)c4)=C3C(=O)N2)cc(Cl)c1OC

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 11/20 0.47
ALDH1A1 P00352 2/20 0.41
HPGD P15428 1/20 0.41
FLT3 P36888 5/20 0.40
GSK3B P49841 5/20 0.40
IGF1R P08069 4/20 0.40
PDGFRB P09619 4/20 0.40
KIT P10721 4/20 0.40
PDGFRA P16234 4/20 0.40
FLT1 P17948 4/20 0.40
FLT4 P35916 4/20 0.40
TEK Q02763 4/20 0.40
EGFR P00533 3/20 0.40
ERBB2 P04626 3/20 0.40
PLK4 O00444 1/20 0.40
AURKA O14965 1/20 0.40
NUAK1 O60285 1/20 0.40
ABL1 P00519 1/20 0.40
INSR P06213 1/20 0.40
MET P08581 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12424924 0.90 KDR (0.38) KDRALDH1A1FLT3GSK3BIGF1R
SCHEMBL10629414 0.80 KDR (0.52) KDRALDH1A1HPGDFLT3GSK3B
SCHEMBL12509903 0.77 TAS1R3 (0.33) KDRALDH1A1GSK3BIGF1RPDGFRB
SCHEMBL12424975 0.73 KDR (0.38) KDRFLT3GSK3BIGF1RPDGFRB
SCHEMBL16024282 0.73 KDM4E (0.51) KDRALDH1A1GSK3BKDM4EMAPT
SCHEMBL25121148 0.71 L3MBTL1 (0.49) KDRALDH1A1HPGDGSK3BMEN1
SCHEMBL25028180 0.68 KDR (0.33) KDR
SCHEMBL12424911 0.68 CES1 (0.36) GSK3B
SCHEMBL286464 0.67 AHR (0.50) GSK3BIGF1RINSRMEN1KMT2A
SCHEMBL12424885 0.67 GSK3A (0.42) ALDH1A1HPGDGSK3BMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7977670-B2 Organic transistor TOYO INK MFG. CO., LTD. (JP) 2011-07-12 US disclosed
US-7977670-B2 Organic transistor TOYO INK MFG. CO., LTD. (JP) 2011-07-12 US disclosed
US-20100032657-A1 ORGANIC TRANSISTOR TOYO INK MFG CO., LTD (JP) 2010-02-11 US disclosed
US-20100032657-A1 ORGANIC TRANSISTOR TOYO INK MFG CO., LTD (JP) 2010-02-11 US disclosed