SCHEMBL12424975

SCHEMBL12424975

COc1c(I)cc(C2=C3C(=O)NC(c4cc(I)c(OC)c(I)c4)=C3C(=O)N2)cc1I

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 12/20 0.38
TPMT P51580 1/20 0.38
IGF1R P08069 4/20 0.36
PDGFRB P09619 4/20 0.36
KIT P10721 4/20 0.36
PDGFRA P16234 4/20 0.36
FLT1 P17948 4/20 0.36
FLT4 P35916 4/20 0.36
TEK Q02763 4/20 0.36
EGFR P00533 3/20 0.36
ERBB2 P04626 3/20 0.36
GSK3B P49841 7/20 0.33
FLT3 P36888 6/20 0.33
PLK4 O00444 1/20 0.33
AURKA O14965 1/20 0.33
NUAK1 O60285 1/20 0.33
ABL1 P00519 1/20 0.33
INSR P06213 1/20 0.33
MET P08581 1/20 0.33
CDK4 P11802 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12509903 0.83 TAS1R3 (0.33) KDRIGF1RPDGFRBKITPDGFRA
SCHEMBL12424924 0.79 KDR (0.38) KDRTPMTIGF1RPDGFRBKIT
SCHEMBL10629414 0.76 KDR (0.52) KDRIGF1RPDGFRBKITPDGFRA
SCHEMBL12424934 0.73 KDR (0.47) KDRIGF1RPDGFRBKITPDGFRA
SCHEMBL1530694 0.69 TTR (0.48) TPMTMCL1KDM4EMAPTTDP1
SCHEMBL7004111 0.68 PTGS2 (0.54) EGFRGSK3BMCL1KDM4EMEN1
SCHEMBL12424967 0.68 GSK3B (0.31) GSK3BMAPT
SCHEMBL22625734 0.68 GABRA1 (0.32)
SCHEMBL16024282 0.68 KDM4E (0.51) KDRGSK3BKDM4EMAPT
SCHEMBL12424753 0.67 DAPK3 (0.30) GSK3BFLT3PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7977670-B2 Organic transistor TOYO INK MFG. CO., LTD. (JP) 2011-07-12 US disclosed
US-7977670-B2 Organic transistor TOYO INK MFG. CO., LTD. (JP) 2011-07-12 US disclosed
US-20100032657-A1 ORGANIC TRANSISTOR TOYO INK MFG CO., LTD (JP) 2010-02-11 US disclosed
US-20100032657-A1 ORGANIC TRANSISTOR TOYO INK MFG CO., LTD (JP) 2010-02-11 US disclosed