SCHEMBL12424924

SCHEMBL12424924

COc1c(Cl)cc(C2=C3C(=O)NC(c4cc(Cl)c(OC)c(Cl)c4)=C3C(=O)N2)cc1Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 2/20 0.38
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
GAA P10253 1/20 0.38
PTGS2 P35354 6/20 0.37
GSK3B P49841 5/20 0.36
PTGS1 P23219 2/20 0.36
GSK3A P49840 2/20 0.36
CHEK1 O14757 1/20 0.35
TPMT P51580 1/20 0.34
GRIN2D O15399 1/20 0.34
GRIN3B O60391 1/20 0.34
GRIN1 Q05586 1/20 0.34
GRIN2A Q12879 1/20 0.34
GRIN2B Q13224 1/20 0.34
GRIN2C Q14957 1/20 0.34
GRIN3A Q8TCU5 1/20 0.34
AKR1B1 P15121 1/20 0.33
STK10 O94804 1/20 0.33
SLK Q9H2G2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12424934 0.90 KDR (0.47) KDRKDM4EALDH1A1GSK3BCHEK1
SCHEMBL12509903 0.86 TAS1R3 (0.33) KDRKDM4EALDH1A1GAAPTGS2
SCHEMBL12424975 0.79 KDR (0.38) KDRKDM4EPTGS2GSK3BTPMT
SCHEMBL12325399 0.73 ALDH1A1 (0.47) KDM4EALDH1A1GAAPTGS2PTGS1
SCHEMBL12424911 0.72 CES1 (0.36) PTGS2GSK3BGSK3A
SCHEMBL10629414 0.72 KDR (0.52) KDRKDM4EALDH1A1GSK3BPLK4
SCHEMBL286464 0.72 AHR (0.50) KDM4EGAAGSK3BGSK3AINSR
SCHEMBL12424885 0.71 GSK3A (0.42) KDM4EALDH1A1GAAPTGS2GSK3B
SCHEMBL12424888 0.69 TDP2 (0.51) PTGS2PTGS1IGF1R
SCHEMBL22625737 0.69 KDM4E (0.37) KDM4EALDH1A1GAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7977670-B2 Organic transistor TOYO INK MFG. CO., LTD. (JP) 2011-07-12 US disclosed
US-20100032657-A1 ORGANIC TRANSISTOR TOYO INK MFG CO., LTD (JP) 2010-02-11 US disclosed