Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC6 | Q9Y210 | 17/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2300760 | 0.84 | HSD11B1 (0.45) | TRPC6GPR119 | |
| SCHEMBL25317444 | 0.73 | GABRA1 (0.44) | TRPC6 | |
| SCHEMBL12425603 | 0.71 | CHRNA4 (0.40) | TRPC6 | |
| SCHEMBL20929521 | 0.66 | NPC1 (0.49) | ALDH1A1 | |
| SCHEMBL12425623 | 0.65 | CDK4 (0.49) | ALDH1A1 | |
| SCHEMBL1713578 | 0.65 | GPR119 (0.38) | GPR119 | |
| SCHEMBL2298739 | 0.64 | SPR (0.46) | GPR119 | |
| SCHEMBL2300794 | 0.64 | HDAC1 (0.52) | GPR119 | |
| SCHEMBL12425428 | 0.64 | HDAC1 (0.55) | GPR119 | |
| SCHEMBL13738462 | 0.63 | MAPK1 (0.41) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101409-A1 | PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 | NOVARTIS AG (CH) | 2011-08-25 | — | — | WO | disclosed |