Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.46 |
| ▸ | TUBB | P07437 | 5/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12426150 | 0.88 | ALDH1A1 (0.45) | TDP1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL12426153 | 0.86 | CYP1A2 (0.56) | TDP1LMNAKMT2ACYP1A2MEN1 | |
| SCHEMBL12426139 | 0.86 | TGFBR1 (0.56) | TDP1LMNAKMT2ACYP1A2MEN1 | |
| SCHEMBL12426134 | 0.85 | TDP1 (0.43) | TDP1LMNAKMT2ACYP1A2MEN1 | |
| SCHEMBL14533159 | 0.84 | CYP1A2 (0.43) | TDP1LMNAKMT2ACYP1A2MEN1 | |
| SCHEMBL12426135 | 0.83 | TGFBR1 (0.53) | TDP1LMNAKMT2ACYP1A2MEN1 | |
| SCHEMBL2203035 | 0.77 | LMNA (0.45) | LMNAKMT2ACYP1A2MEN1CYP3A4 | |
| SCHEMBL14504469 | 0.77 | TDP1 (0.43) | TDP1LMNAKMT2ACYP1A2MEN1 | |
| SCHEMBL12426145 | 0.76 | CYP1A2 (0.43) | TDP1LMNAKMT2ACYP1A2MEN1 | |
| SCHEMBL12426110 | 0.76 | TGFBR1 (0.56) | TDP1LMNAKMT2ACYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977342-B2 | HCV inhibiting bi-cyclic pyrimidines | TIBOTEC-VIRCO VIROLOGY BVBA (BE) | 2011-07-12 | — | — | US | disclosed |
| US-7977342-B2 | HCV inhibiting bi-cyclic pyrimidines | TIBOTEC-VIRCO VIROLOGY BVBA (BE) | 2011-07-12 | — | — | US | disclosed |
| US-20070155716-A1 | HCV INHIBITING BI-CYCLIC PYRIMIDINES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2007-07-05 | — | — | US | disclosed |
| US-20070155716-A1 | HCV INHIBITING BI-CYCLIC PYRIMIDINES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2007-07-05 | — | — | US | disclosed |
| US-7223766-B2 | Bi-cyclic pyrimidine inhibitors of TGFβ | SCIOS, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| US-7223766-B2 | Bi-cyclic pyrimidine inhibitors of TGFβ | SCIOS, INC. (US) | 2007-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155716-A1 | HCV INHIBITING BI-CYCLIC PYRIMIDINES | UMPS, NUDT1, PNP | TDP1 930/4885LMNA 4118/4885KMT2A 3844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.