Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24506814 | 0.86 | ADORA2A (0.48) | ADORA2APIK3CG | |
| SCHEMBL12775538 | 0.84 | ADORA1 (0.36) | ADORA2APIK3CGNOS1PIK3CAPIK3CB | |
| SCHEMBL30965441 | 0.76 | ADORA2A (0.53) | ADORA2APIK3CGNOS1PIK3CAPIK3CB | |
| SCHEMBL63822 | 0.76 | ADORA2A (0.53) | ADORA2APIK3CGNOS1PIK3CAPIK3CB | |
| SCHEMBL3692533 | 0.75 | ADORA2A (0.57) | ADORA2APIK3CGNOS1PIK3CAPIK3CB | |
| SCHEMBL16980950 | 0.75 | NOS1 (0.53) | NOS1 | |
| Bromide SCHEMBL11633687 | 0.74 | ADORA2A (0.52) | ADORA2APIK3CGNOS1PIK3CAPIK3CB | |
| SCHEMBL3537607 | 0.73 | ADORA2A (0.55) | ADORA2APIK3CGNOS1PIK3CAPIK3CB | |
| SCHEMBL25449339 | 0.73 | ALDH1A1 (0.35) | — | |
| SCHEMBL3660280 | 0.72 | ADORA2A (0.53) | ADORA2APIK3CGNOS1PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117552-B1 | USE OF CONDENSED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES | STOICESCU DAN (CH) | 2011-08-03 | — | — | EP | disclosed |
| US-7875716-B2 | Such as n-[4-[[2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]pseudoglutamic ester; synthesis; efficacy; reduced renal toxicity and other adverse side effects; cancer | STOICESCU DAN | 2011-01-25 | — | — | US | disclosed |
| US-7718660-B2 | Inhibitors of folic acid-dependent enzymes | STOICESCU DAN | 2010-05-18 | — | — | US | disclosed |
| US-20080214550-A1 | Novel inhibitors of folic acid-dependent enzymes | STOICESCU DAN | 2008-09-04 | — | — | US | disclosed |
| WO-2008098957-A1 | USE OF CONDENSED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES | STOICESCU DAN (CH) | 2008-08-21 | — | — | WO | disclosed |
| EP-1958632-A1 | Use of condensed pyrimidine derivatives for the treatment of autoimmune and inflammatory diseases | Stoicescu, Dan (CY) | 2008-08-20 | — | — | EP | disclosed |
| EP-1809292-B1 | CONDENSED PYRIMIDINE DERIVATIVES AS INHIBITORS OF FOIC ACID-DEPENDENT ENZYMES | STOICESCU DAN (CH) | 2008-05-21 | — | — | EP | disclosed |
| US-20070265444-A1 | Novel Inhibitors of Folic Acid-Dependent Enzymes | STOICESCU DAN | 2007-11-15 | — | — | US | disclosed |
| WO-2007020277-A2 | CONDENSED PYRIMIDINE DERIVATIVES AS INHIBITORS OF FOIC ACID-DEPENDENT ENZYMES | STOICESCU DAN (CY) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265444-A1 | Novel Inhibitors of Folic Acid-Dependent Enzymes | FOLR2, FOLR1, DHFR | ADORA2A 844/4885PIK3CG 4242/4885NOS1 1678/4885 |
| US-20080214550-A1 | Novel inhibitors of folic acid-dependent enzymes | FOLR2, FOLR1, DHFR | ADORA2A 850/4885PIK3CG 4317/4885NOS1 1459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.