Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LPL | P06858 | 1/20 | 0.44 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9022670 | 0.87 | PLK1 (0.53) | PLK1GAAALDH1A1POLBCTDSP1 | |
| SCHEMBL8448673 | 0.87 | PLK1 (0.53) | PLK1GAAALDH1A1POLBCTDSP1 | |
| SCHEMBL7801088 | 0.87 | PLK1 (0.53) | PLK1GAAALDH1A1POLBCTDSP1 | |
| SCHEMBL9220484 | 0.83 | PLK1 (0.50) | PLK1GAAALDH1A1POLBCTDSP1 | |
| SCHEMBL9399023 | 0.83 | PLK1 (0.50) | PLK1GAAALDH1A1POLBCTDSP1 | |
| SCHEMBL9399014 | 0.83 | PLK1 (0.50) | PLK1GAAALDH1A1POLBCTDSP1 | |
| SCHEMBL9124458 | 0.80 | PLK1 (0.47) | PLK1GAAALDH1A1POLBCTDSP1 | |
| SCHEMBL9124443 | 0.80 | PLK1 (0.47) | PLK1GAAALDH1A1POLBCTDSP1 | |
| SCHEMBL9124450 | 0.80 | PLK1 (0.47) | PLK1GAAALDH1A1POLBCTDSP1 | |
| SCHEMBL7230860 | 0.80 | THRB (0.50) | PLK1GAAALDH1A1POLBCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2182041-B1 | Liquid crystal medium comprising 1,2-difluorethene compounds, and liquid crystal display | MERCK PATENT GMBH (DE) | 2011-08-10 | — | — | EP | disclosed |
| US-7923079-B2 | Liquid-crystalline medium and liquid-crystal display comprising 1,2-difluoroethene compounds | MERCK PATENT GMBH (DE) | 2011-04-12 | — | — | US | disclosed |
| US-7923079-B2 | Liquid-crystalline medium and liquid-crystal display comprising 1,2-difluoroethene compounds | MERCK PATENT GMBH (DE) | 2011-04-12 | — | — | US | disclosed |
| EP-2182041-A2 | Liquid crystal medium comprising 1,2-difluorethene compounds, and liquid crystal display | MERCK PATENT GmbH (DE) | 2010-05-05 | — | — | EP | disclosed |
| US-20100085529-A1 | LIQUID-CRYSTALLINE MEDIUM AND LIQUID-CRYSTAL DISPLAY COMPRISING 1,2-DIFLUOROETHENE COMPOUNDS | WITTEK MICHAEL | 2010-04-08 | — | — | US | disclosed |
| US-20100085529-A1 | LIQUID-CRYSTALLINE MEDIUM AND LIQUID-CRYSTAL DISPLAY COMPRISING 1,2-DIFLUOROETHENE COMPOUNDS | WITTEK MICHAEL | 2010-04-08 | — | — | US | disclosed |
| EP-1891181-B1 | LIQUID-CRYSTALLINE MEDIUM AND LIQUID CRYSTAL DISPLAY WITH 1,2-DIFLUOROETHENE COMPOUNDS | MERCK PATENT GMBH (DE) | 2010-02-17 | — | — | EP | disclosed |
| US-7651742-B2 | Liquid-crystalline medium and liquid-crystal display comprising 1,2-difluoroethene compounds | MERCK PATENT GMBH (DE) | 2010-01-26 | — | — | US | disclosed |
| US-7651742-B2 | Liquid-crystalline medium and liquid-crystal display comprising 1,2-difluoroethene compounds | MERCK PATENT GMBH (DE) | 2010-01-26 | — | — | US | disclosed |
| US-20080260971-A1 | Liquid-Crystalline Medium and Liquid-Crystal Display Comprising 1,2-Difluoroethene Compounds | MERCK PATENT GMBH (DE) | 2008-10-23 | — | — | US | disclosed |
| US-20080260971-A1 | Liquid-Crystalline Medium and Liquid-Crystal Display Comprising 1,2-Difluoroethene Compounds | MERCK PATENT GMBH (DE) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080260971-A1 | Liquid-Crystalline Medium and Liquid-Crystal Display Comprising 1,2-Difluoroethene Compounds | CFL1, NEFM, CHRM1 | PLK1 1117/4885GAA 3865/4885ALDH1A1 649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.