SCHEMBL9220484

SCHEMBL9220484

CCCc1ccc(C(F)=C(F)F)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLK1 P53350 2/20 0.50
THRB P10828 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.47
LPL P06858 1/20 0.47
LIPG Q9Y5X9 1/20 0.47
ALDH1A1 P00352 3/20 0.44
POLB P06746 3/20 0.44
CTDSP1 Q9GZU7 3/20 0.44
GAA P10253 3/20 0.44
KDM4E B2RXH2 1/20 0.44
NPC1 O15118 3/20 0.43
RAB9A P51151 3/20 0.43
KMT2A Q03164 2/20 0.43
MAPT P10636 1/20 0.43
LMNA P02545 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
ESR1 P03372 1/20 0.42
ESR2 Q92731 1/20 0.42
CNR1 P21554 1/20 0.41
CNR2 P34972 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9022670 0.91 PLK1 (0.53) PLK1THRBL3MBTL1LPLLIPG
SCHEMBL8448673 0.91 PLK1 (0.53) PLK1THRBL3MBTL1LPLLIPG
SCHEMBL7801088 0.91 PLK1 (0.53) PLK1THRBL3MBTL1LPLLIPG
SCHEMBL9399023 0.87 PLK1 (0.50) PLK1THRBL3MBTL1LPLLIPG
SCHEMBL9399014 0.87 PLK1 (0.50) PLK1THRBL3MBTL1LPLLIPG
SCHEMBL7230860 0.83 THRB (0.50) PLK1THRBL3MBTL1LPLLIPG
SCHEMBL9124443 0.83 PLK1 (0.47) PLK1THRBL3MBTL1LPLLIPG
SCHEMBL9124458 0.83 PLK1 (0.47) PLK1THRBL3MBTL1LPLLIPG
SCHEMBL12437965 0.83 PLK1 (0.47) PLK1THRBL3MBTL1LPLLIPG
SCHEMBL9124450 0.83 PLK1 (0.47) PLK1THRBL3MBTL1LPLLIPG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3524646-B1 IONIC COMPOUND, COATING COMPOSITION COMPRISING SAME, AND ORGANIC LIGHT-EMITTING DIODE LG CHEMICAL LTD (KR) 2021-07-21 EP disclosed
US-20140128560-A1 PROCESS TO PREPARE CROSSLINKABLE TRIFLUOROSTYRENE POLYMERS AND MEMBRANES E I DU PONT DE NEMOURS AND COMPANY (US) 2014-05-08 US disclosed
US-20110046247-A1 CROSSLINKABLE MONOMER E.I. DU PONT DE NEMOURS AND COMPANY (US) 2011-02-24 US disclosed
US-5380461-A Trans-dihalogenostilbene compounds and liquid crystal electro-optical devices using them SEIMI CHEMICAL CO., LTD. (JP) 1995-01-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140128560-A1 PROCESS TO PREPARE CROSSLINKABLE TRIFLUOROSTYRENE POLYMERS AND MEMBRANES STOM, PXMP4, TMSB4X PLK1 2217/4885THRB 3780/4885L3MBTL1 4734/4885
US-20110046247-A1 CROSSLINKABLE MONOMER MFAP1, FGB, PFDN6 PLK1 3686/4885THRB 3196/4885L3MBTL1 1148/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.