Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.52 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12513598 | 0.84 | LMNA (0.54) | TMEM97SIGMAR1ALDH1A1LMNASLC22A2 | |
| SCHEMBL1134991 | 0.84 | PKM (0.63) | ALDH1A1LMNASLC22A2SLC22A1TSHR | |
| SCHEMBL12438399 | 0.83 | ALDH1A1 (0.52) | TMEM97SIGMAR1ALDH1A1LMNASLC22A2 | |
| SCHEMBL12438407 | 0.83 | ALDH1A1 (0.52) | TMEM97SIGMAR1ALDH1A1LMNASLC22A2 | |
| SCHEMBL1135013 | 0.83 | LMNA (0.52) | TMEM97SIGMAR1ALDH1A1LMNASLC22A2 | |
| SCHEMBL12438394 | 0.82 | DRD2 (0.54) | ALDH1A1CYP2C19POLBSMN1; SMN2ATM | |
| SCHEMBL1135005 | 0.81 | ALDH1A1 (0.50) | TMEM97SIGMAR1ALDH1A1LMNASLC22A2 | |
| SCHEMBL12391541 | 0.78 | ALDH1A1 (0.72) | TMEM97SIGMAR1ALDH1A1LMNASLC22A2 | |
| SCHEMBL6553954 | 0.76 | KMT2A (0.59) | ALDH1A1LMNASLC22A2SLC22A1TSHR | |
| Hydrochloric Acid SCHEMBL8010729 | 0.75 | LMNA (0.58) | ALDH1A1LMNASLC22A2SLC22A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178396-A1 | Nicotinamide Derivatives | CRC FOR BIOMEDICAL IMAGING DEVELOPMENT LTD. (AU) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178396-A1 | Nicotinamide Derivatives | NAMPT, NNT, NNMT | TMEM97 3153/4885SIGMAR1 3244/4885ALDH1A1 883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.