Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL805507 | 0.69 | GNAI3 (0.50) | KMT2AHTTSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL28729089 | 0.69 | FFAR3 (0.35) | — | |
| SCHEMBL25074352 | 0.67 | GNAI3 (0.54) | KMT2AHTTSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL25074008 | 0.67 | GNAI3 (0.54) | KMT2AHTTSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL25074011 | 0.67 | GNAI3 (0.54) | KMT2AHTTSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL11240 | 0.67 | L3MBTL1 (0.62) | KMT2AHTTSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL20825137 | 0.66 | KMT2A (0.32) | KMT2A | |
| SCHEMBL6044018 | 0.66 | TDP1 (0.50) | KMT2AHTTSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL6044015 | 0.66 | TDP1 (0.50) | KMT2AHTTSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL27314179 | 0.66 | GNAI3 (0.42) | KMT2AHTTSMN1; SMN2GNAI3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |