Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | CTSG | P08311 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | CTRC | Q99895 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28050493 | 0.81 | KMT2A (0.49) | HTTALDH1A1POLBKMT2ANOTUM | |
| SCHEMBL16045938 | 0.81 | ALDH1A1 (0.44) | HTTALDH1A1KMT2ANOTUMKDM4E | |
| SCHEMBL1060286 | 0.81 | P2RX7 (0.56) | HTTALDH1A1POLBKMT2AKDM4E | |
| SCHEMBL4251316 | 0.80 | MEN1 (0.54) | HTTALDH1A1KMT2AHPGDNPC1 | |
| SCHEMBL3116927 | 0.80 | PTGS2 (0.48) | HTT | |
| SCHEMBL23036953 | 0.79 | MTOR (0.52) | HTTALDH1A1KMT2AKDM4EHPGD | |
| SCHEMBL12422701 | 0.78 | HTT (0.59) | HTTALDH1A1POLBKMT2ANOTUM | |
| SCHEMBL5149995 | 0.77 | ALDH1A1 (0.44) | HTTALDH1A1POLBNOTUMKDM4E | |
| SCHEMBL2217122 | 0.77 | UBE2N (0.43) | ALDH1A1NOTUMUBE2NNPC1RAB9A | |
| SCHEMBL19457078 | 0.76 | HTT (0.67) | HTTALDH1A1POLBKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8334317-B2 | Calcium receptor modulating agents | AMGEN INC. (US) | 2012-12-18 | — | — | US | disclosed |
| CN-101544634-B | 2-phenyl-3-substituted pyrazolo[1,5-a]pyridine derivatives, preparation method and application thereof | TIANJIN INST PHARM RESEARCH | 2011-08-10 | — | — | CN | disclosed |
| US-20110178133-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. | 2011-07-21 | — | — | US | disclosed |
| CN-101544634-A | 2-phenyl-3-substituted pyrazolo[1,5-a]pyridine derivatives, preparation method and application thereof | TIANJIN INST PHARM RESEARCH | 2009-09-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178133-A1 | CALCIUM RECEPTOR MODULATING AGENTS | CASR, CALCR, RYR1 | HTT 3407/4885ALDH1A1 3977/4885POLB 4841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.