Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.47 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 11/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12446237 | 0.85 | BACE1 (0.47) | BACE1BACE2GRM4 | |
| SCHEMBL12445675 | 0.85 | BACE1 (0.49) | BACE1BACE2GRM4 | |
| SCHEMBL12445674 | 0.85 | BACE1 (0.47) | BACE1BACE2GRM4 | |
| SCHEMBL7941942 | 0.77 | SORT1 (0.41) | BACE1GRM4 | |
| SCHEMBL7945392 | 0.76 | BACE1 (0.59) | BACE1BACE2GRM4 | |
| SCHEMBL12445846 | 0.75 | GRM4 (0.38) | BACE1GRM4 | |
| SCHEMBL12445479 | 0.75 | BACE1 (0.58) | BACE1BACE2GRM4 | |
| SCHEMBL12445874 | 0.74 | ALDH1A1 (0.37) | BACE1GRM4 | |
| SCHEMBL12446239 | 0.71 | PRKCI (0.40) | BACE1BACE2 | |
| SCHEMBL12446184 | 0.70 | BACE1 (0.53) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |