Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 13/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12445472 | 0.85 | BACE1 (0.41) | RAB9ABACE1 | |
| SCHEMBL12445675 | 0.81 | BACE1 (0.49) | GRM4BACE1 | |
| SCHEMBL7939939 | 0.77 | BACE1 (0.55) | GRM4PRKCIBACE1 | |
| SCHEMBL12446237 | 0.77 | BACE1 (0.47) | GRM4PRKCIRAB9ANPC1BACE1 | |
| SCHEMBL12445674 | 0.76 | BACE1 (0.47) | GRM4PRKCIBACE1 | |
| SCHEMBL7941942 | 0.76 | SORT1 (0.41) | GRM4PRKCIRAB9ANPC1BACE1 | |
| SCHEMBL12445871 | 0.75 | BACE1 (0.47) | GRM4BACE1 | |
| SCHEMBL12445874 | 0.74 | ALDH1A1 (0.37) | GRM4PRKCIRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL12446239 | 0.71 | PRKCI (0.40) | PRKCIBACE1 | |
| SCHEMBL7946451 | 0.70 | BACE1 (0.55) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |