Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 13/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.35 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | MDM4 | O15151 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13320072 | 0.77 | MDM2 (0.68) | MDM2TP53MDM4 | |
| SCHEMBL12445916 | 0.74 | MDM2 (0.44) | MDM2TP53MDM4POLB | |
| SCHEMBL12446085 | 0.73 | MDM2 (0.55) | MDM2TP53MDM4 | |
| SCHEMBL12446512 | 0.72 | HTT (0.46) | MDM2TP53MDM4 | |
| SCHEMBL12446087 | 0.71 | MDM2 (0.44) | MDM2TP53ALDH1A1HSD17B10MDM4 | |
| SCHEMBL7948520 | 0.71 | MDM2 (0.41) | MDM2TP53MDM4 | |
| SCHEMBL7952593 | 0.70 | P2RX7 (0.40) | MDM2TP53MDM4 | |
| SCHEMBL12446587 | 0.70 | LMNA (0.46) | MDM2TP53HPGDNPSR1LMNA | |
| SCHEMBL12446511 | 0.70 | MDM2 (0.54) | MDM2TP53SMN1; SMN2ALDH1A1MDM4 | |
| SCHEMBL13571868 | 0.70 | MDM2 (0.55) | MDM2TP53MDM4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010031713-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-25 | — | — | WO | disclosed |