Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245348 | 1.00 | MEN1 (0.53) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL1245346 | 1.00 | MEN1 (0.53) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL1244738 | 0.91 | KMT2A (0.57) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL1244737 | 0.91 | KMT2A (0.57) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL7074293 | 0.86 | MEN1 (0.68) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL3404716 | 0.85 | ADRB2 (0.56) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL3404710 | 0.85 | ADRB2 (0.56) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL2879966 | 0.84 | MEN1 (0.66) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL18726389 | 0.84 | ADRB2 (0.55) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL18725919 | 0.84 | ADRB2 (0.55) | MEN1KMT2AADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2986288-B1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NICOX SCIENCE IRELAND (IE) | 2017-04-12 | — | — | EP | disclosed |
| US-9598349-B2 | Quinone based nitric oxide donating compounds for ophthalmic use | NICOX SCIENCE IRELAND (IE) | 2017-03-21 | — | — | US | disclosed |
| US-20160145192-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NICOX SA (FR) | 2016-05-26 | — | — | US | disclosed |
| EP-2986288-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | Nicox Science Ireland (IE) | 2016-02-24 | — | — | EP | disclosed |
| WO-2014170262-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NICOX SCIENCE IRELAND (IE) | 2014-10-23 | — | — | WO | disclosed |
| WO-2014170264-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NICOX SCIENCE IRELAND (IE) | 2014-10-23 | — | — | WO | disclosed |
| WO-2011012400-A2 | NITRIC OXIDE RELEASING NAPROXEN | NICOX S.A. (FR) | 2011-02-03 | — | — | WO | disclosed |
| US-7622502-B2 | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors | MERCK FROSST CANADA & CO. (CA) | 2009-11-24 | — | — | US | disclosed |
| US-20080242722-A1 | Combination Therapy for Treating Cyclooxygenase-2 Mediated Diseases or Conditions in Patients at Risk of Thrombotic Cardiovascular Events | DUFRESNE CLAUDE | 2008-10-02 | — | — | US | disclosed |
| US-20080227758-A1 | Nitric Oxide Releasing Prodrugs of Diaryl-2-(5h)-Furanones as Cyclooxygenase-2 Inhibitors | BERTHELETTE CARL | 2008-09-18 | — | — | US | disclosed |
| US-20080227758-A1 | Nitric Oxide Releasing Prodrugs of Diaryl-2-(5h)-Furanones as Cyclooxygenase-2 Inhibitors | BERTHELETTE CARL | 2008-09-18 | — | — | US | disclosed |
| EP-1711457-A4 | NITRIC OXIDE RELEASING PRODRUGS OF DIARYL-2-(5H)-FURANONES AS CYCLOOXYGENASE-2 INHIBITORS | MERCK FROSST COMPANY (CA) | 2008-01-09 | — | — | EP | disclosed |
| EP-1711454-A4 | COMBINATION THERAPY FOR TREATING CYCLOOXYGENASE-2 MEDIATED DISEASES OR CONDITIONS IN PATIENTS AT RISK OF THROMBOTIC CARDIOVASCULAR EVENTS | MERCK FROSST COMPANY (CA) | 2007-04-04 | — | — | EP | disclosed |
| EP-1711454-A1 | COMBINATION THERAPY FOR TREATING CYCLOOXYGENASE-2 MEDIATED DISEASES OR CONDITIONS IN PATIENTS AT RISK OF THROMBOTIC CARDIOVASCULAR EVENTS | Merck Frosst Company (CA) | 2006-10-18 | — | — | EP | disclosed |
| EP-1711457-A1 | NITRIC OXIDE RELEASING PRODRUGS OF DIARYL-2-(5H)-FURANONES AS CYCLOOXYGENASE-2 INHIBITORS | Merck Frosst Company (CA) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005070874-A1 | NITRIC OXIDE RELEASING PRODRUGS OF DIARYL-2-(5H)-FURANONES AS CYCLOOXYGENASE-2 INHIBITORS | MERCK FROSST COMPANY (CA) | 2005-08-04 | — | — | WO | disclosed |
| WO-2005070868-A1 | COMBINATION THERAPY FOR TREATING CYCLOOXYGENASE-2 MEDIATED DISEASES OR CONDITIONS IN PATIENTS AT RISK OF THROMBOTIC CARDIOVASCULAR EVENTS | MERCK FROSST COMPANY (CA) | 2005-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242722-A1 | Combination Therapy for Treating Cyclooxygenase-2 Mediated Diseases or Conditions in Patients at Risk of Thrombotic Cardiovascular Events | PTGS2, PTGS1, PTGES2 | MEN1 4123/4885KMT2A 3588/4885ADRB2 2038/4885 |
| US-20080227758-A1 | Nitric Oxide Releasing Prodrugs of Diaryl-2-(5h)-Furanones as Cyclooxygenase-2 Inhibitors | PTGIS, PTGS1, PTGS2 | MEN1 3275/4885KMT2A 3933/4885ADRB2 1624/4885 |
| US-20160145192-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NQO1, NOS1, NOS2 | MEN1 1189/4885KMT2A 2334/4885ADRB2 960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.