Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1702752 | 0.81 | PTGS2 (0.42) | ALDH1A1LMNAMAPTMAPK1XBP1 | |
| SCHEMBL28647295 | 0.80 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPTMAPK1XBP1 | |
| SCHEMBL8201126 | 0.76 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPTMAPK1XBP1 | |
| SCHEMBL11477347 | 0.73 | PTGS2 (0.47) | ALDH1A1LMNAMAPTMAPK1PTGS2 | |
| Ethane SCHEMBL5679245 | 0.72 | ALDH1A1 (0.51) | ALDH1A1LMNAMAPTMAPK1XBP1 | |
| SCHEMBL2566022 | 0.72 | ALDH1A1 (0.51) | ALDH1A1LMNAMAPTMAPK1XBP1 | |
| SCHEMBL3289274 | 0.72 | ALDH1A1 (0.51) | ALDH1A1LMNAMAPTMAPK1XBP1 | |
| SCHEMBL2566020 | 0.72 | ALDH1A1 (0.51) | ALDH1A1LMNAMAPTMAPK1XBP1 | |
| SCHEMBL12387037 | 0.71 | ALDH1A1 (0.47) | ALDH1A1LMNAMAPTMAPK1XBP1 | |
| SCHEMBL393440 | 0.71 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPTMAPK1XBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110082200-A1 | 5,6,7-TRIHYDROXYHEPTANOIC ACID AND ANALOGS FOR THE TREATMENT OF OCULAR DISEASES AND DISEASES ASSOCIATED WITH HYPERPROLIFERATIVE AND ANGIOGENIC RESPONSES | ALCON, INC. (CH) | 2011-04-07 | — | — | US | disclosed |
| US-7879905-B2 | treating persons suffering from age-related macular degeneration comprising administering 5,6,7-trihydroxyheptanoic acid analogs such as 5,6,7-trihydroxyheptanoic acid, methyl ester; vision defects | ALCON, INC. (CH) | 2011-02-01 | — | — | US | disclosed |
| EP-1809270-B1 | 5,6,7-TRIHYDROXYHEPTANOIC ACID AND ANALOGS FOR THE TREATMENT OF OCULAR DISEASES AND DISEASES ASSOCIATED WITH HYPERPROLIFERATIVE AND ANGIOGENIC RESPONSES | ALCON INC (CH) | 2010-03-24 | — | — | EP | disclosed |
| EP-1809270-A1 | 5,6,7-TRIHYDROXYHEPTANOIC ACID AND ANALOGS FOR THE TREATMENT OF OCULAR DISEASES AND DISEASES ASSOCIATED WITH HYPERPROLIFERATIVE AND ANGIOGENIC RESPONSES | ALCON INC. (CH) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006052950-A1 | 5,6,7-TRIHYDROXYHEPTANOIC ACID AND ANALOGS FOR THE TREATMENT OF OCULAR DISEASES AND DISEASES ASSOCIATED WITH HYPERPROLIFERATIVE AND ANGIOGENIC RESPONSES | ALCON, INC. (CH) | 2006-05-18 | — | — | WO | disclosed |
| US-20060099248-A1 | 5,6,7-Trihydroxyheptanoic acid and analogs for the treatment of ocular diseases and diseases associated with hyperproliferative and angiogenic responses | ALCON, INC. | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060099248-A1 | 5,6,7-Trihydroxyheptanoic acid and analogs for the treatment of ocular diseases and diseases associated with hyperproliferative and angiogenic responses | HPGDS, ADCYAP1R1, VEGFA | ALDH1A1 1105/4885LMNA 2852/4885MAPT 4277/4885 |
| US-20110082200-A1 | 5,6,7-TRIHYDROXYHEPTANOIC ACID AND ANALOGS FOR THE TREATMENT OF OCULAR DISEASES AND DISEASES ASSOCIATED WITH HYPERPROLIFERATIVE AND ANGIOGENIC RESPONSES | HPGDS, ADCYAP1R1, VEGFA | ALDH1A1 1105/4885LMNA 2852/4885MAPT 4277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.