Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | MGAM | O43451 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 5/20 | 0.45 |
| ▸ | SI | P14410 | 5/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HAT1 | O14929 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1714010 | 1.00 | MTNR1A (0.46) | MTNR1AMTNR1BMGAMGAASI | |
| SCHEMBL2072930 | 0.91 | MTNR1A (0.43) | MTNR1AMTNR1BMGAMGAASI | |
| SCHEMBL3151911 | 0.86 | SLC6A2 (0.44) | MTNR1AMTNR1BMGAMGAASI | |
| SCHEMBL3224972 | 0.82 | HPGD (0.41) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL1714532 | 0.81 | SLC6A4 (0.64) | MTNR1AMTNR1BLMNACYP2D6SLC6A2 | |
| SCHEMBL2073643 | 0.81 | SLC6A4 (0.64) | MTNR1AMTNR1BLMNACYP2D6SLC6A2 | |
| SCHEMBL1714535 | 0.81 | SLC6A4 (0.64) | MTNR1AMTNR1BLMNACYP2D6SLC6A2 | |
| Hydrochloric Acid SCHEMBL2071436 | 0.80 | SLC6A2 (0.63) | MTNR1AMTNR1BCYP2D6SLC6A2SLC6A4 | |
| Iodide SCHEMBL2071562 | 0.80 | SLC6A2 (0.63) | MTNR1AMTNR1BLMNACYP2D6SLC6A2 | |
| Hydrochloric Acid SCHEMBL2071435 | 0.80 | SLC6A2 (0.63) | MTNR1AMTNR1BCYP2D6SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957454-B1 | METHODS FOR SYNTHESIS OF 3-AMINO-1-ARYLPROPYL INDOLES | HOFFMANN LA ROCHE (CH) | 2011-07-20 | — | — | EP | disclosed |
| US-7598399-B2 | Methods for synthesis of 3-amino-1-arylpropyl indoles | ROCHE PALO ALTO LLC (US) | 2009-10-06 | — | — | US | disclosed |
| US-20070135647-A1 | Methods for synthesis of 3-amino-1-arylpropyl indoles | ROCHE PALO ALTO LLC | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135647-A1 | Methods for synthesis of 3-amino-1-arylpropyl indoles | TPH1, TPH2, HTR1A | MTNR1A 25/4885MTNR1B 38/4885MGAM 3927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.