Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1246467 | 0.88 | NR1H4 (0.43) | SCN9AGPBAR1NR1H4PTGS2 | |
| SCHEMBL3707177 | 0.88 | LPAR1 (0.34) | SCN9ANR1H4PPARGKDM4ETP53 | |
| SCHEMBL1247108 | 0.87 | SCN9A (0.40) | SCN9AGPBAR1NR1H4PPARGKDM4E | |
| SCHEMBL1246307 | 0.86 | NR1H4 (0.44) | SCN9AGPBAR1NR1H4MAPTTDP1 | |
| SCHEMBL1247381 | 0.85 | ICMT (0.41) | SCN9ANR1H4PPARGKDM4EMAPT | |
| SCHEMBL2338259 | 0.84 | LPAR1 (0.39) | NR1H4PPARGKDM4EPPARAALDH1A1 | |
| SCHEMBL1247132 | 0.84 | GPBAR1 (0.44) | GPBAR1MAPTKMT2AGAATSHR | |
| SCHEMBL1247124 | 0.84 | NR1H4 (0.43) | SCN9AGPBAR1NR1H4MAPTTDP1 | |
| SCHEMBL1246465 | 0.84 | NR1H4 (0.45) | SCN9AGPBAR1NR1H4TP53MAPT | |
| SCHEMBL1245358 | 0.83 | NR1H4 (0.42) | SCN9AGPBAR1NR1H4MAPTPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |