Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.38 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1246346 | 0.90 | SCN9A (0.38) | MAPTALDH1A1NR1H4SCN9APLA2G2A | |
| SCHEMBL1245320 | 0.90 | NR1H4 (0.45) | MAPTALDH1A1HPGDPOLBLMNA | |
| SCHEMBL1247222 | 0.89 | ALDH1A1 (0.36) | MAPTALDH1A1HPGDPOLBLMNA | |
| SCHEMBL1247124 | 0.88 | NR1H4 (0.43) | MAPTALDH1A1HPGDPOLBLMNA | |
| SCHEMBL1245111 | 0.88 | NR1H4 (0.50) | HPGDLMNANR1H4MRGPRX4NPC1 | |
| SCHEMBL1245176 | 0.87 | NR1H4 (0.40) | MAPTALDH1A1HPGDPOLBNR1H4 | |
| SCHEMBL1247564 | 0.87 | MAPT (0.42) | MAPTALDH1A1HPGDPOLBLMNA | |
| SCHEMBL3706744 | 0.87 | IP6K1 (0.43) | MAPTALDH1A1HPGDLMNAIP6K1 | |
| SCHEMBL1246422 | 0.86 | KMO (0.41) | MAPTALDH1A1HPGDPOLBLMNA | |
| SCHEMBL1245358 | 0.83 | NR1H4 (0.42) | MAPTALDH1A1HPGDPOLBNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |