Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1247798 | 0.92 | KDM4E (0.37) | KDM4ETP53SCN9ANPC1 | |
| SCHEMBL1245136 | 0.90 | NR1H4 (0.38) | PPARGPPARDPPARANR3C1PTGDR2 | |
| SCHEMBL1245270 | 0.87 | KDM4E (0.44) | KDM4EPPARDTP53SCN9ANPC1 | |
| SCHEMBL3712290 | 0.87 | NR3C1 (0.38) | KDM4ENR3C1SRD5A2PTGDR2TP53 | |
| SCHEMBL1247289 | 0.86 | KDM4E (0.39) | KDM4EPPARGPPARDPPARATP53 | |
| SCHEMBL1247569 | 0.83 | SCN9A (0.39) | KDM4EPPARDTP53SCN9ANPC1 | |
| SCHEMBL1246477 | 0.82 | NR1H4 (0.42) | PPARGPPARDPPARAPTGDR2 | |
| SCHEMBL1246914 | 0.80 | KDM4E (0.39) | KDM4EPPARGPPARDPPARATP53 | |
| SCHEMBL9902690 | 0.80 | L3MBTL1 (0.42) | KDM4EPPARGSCN9ANPC1 | |
| SCHEMBL1247343 | 0.80 | PTGS2 (0.42) | PPARDFFAR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |