Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.47 |
| ▸ | CHUK | O15111 | 1/20 | 0.47 |
| ▸ | CASR | P41180 | 5/20 | 0.46 |
| ▸ | ACHE | P22303 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24277027 | 0.85 | MAOA (0.48) | MAOAMAOBKDM4EGAAHASPIN | |
| SCHEMBL19268262 | 0.84 | KDM4E (0.60) | MAOAMAOBKDM4EGAACASR | |
| SCHEMBL20147149 | 0.83 | MAOA (0.46) | MAOAMAOBKDM4EGAAHASPIN | |
| SCHEMBL16640338 | 0.81 | DYRK1A (0.50) | HASPINACHEHTTBCHEROCK2 | |
| SCHEMBL12464614 | 0.81 | MAPT (0.64) | MAOAMAOBKDM4EGAAHASPIN | |
| SCHEMBL29445072 | 0.80 | TP53 (0.44) | MAOAMAOBKDM4EGAAHASPIN | |
| SCHEMBL24276800 | 0.80 | TP53 (0.44) | MAOAMAOBKDM4EGAAHASPIN | |
| SCHEMBL2719167 | 0.79 | CHUK (0.42) | CHUKMAPTMEN1KMT2AHTT | |
| SCHEMBL4166593 | 0.79 | HASPIN (0.52) | MAOAMAOBHASPINCHUKACHE | |
| SCHEMBL16640336 | 0.78 | DYRK1A (0.45) | MAOAMAOBACHEMAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9107914-B2 | Beta-carbolines for use in the treatment of hearing loss and vertigo | AUDIOCURE PHARMA GMBH (DE) | 2015-08-18 | — | — | US | claimed |
| EP-2519238-B1 | BETA-CARBOLINES FOR THE TREATMENT OF HEARING LOSS AND VERTIGO | AUDIOCURE PHARMA GMBH (DE) | 2014-08-13 | — | — | EP | claimed |
| US-20130028958-A1 | BETA-CARBOLINES FOR USE IN THE TREATMENT OF HEARING LOSS AND VERTIGO | AUDIOCURE PHARMA GMBH (DE) | 2013-01-31 | — | — | US | claimed |
| US-9107914-B2 | Beta-carbolines for use in the treatment of hearing loss and vertigo | AUDIOCURE PHARMA GMBH (DE) | 2015-08-18 | — | — | US | disclosed |
| EP-2519238-B1 | BETA-CARBOLINES FOR THE TREATMENT OF HEARING LOSS AND VERTIGO | AUDIOCURE PHARMA GMBH (DE) | 2014-08-13 | — | — | EP | disclosed |
| US-20130028958-A1 | BETA-CARBOLINES FOR USE IN THE TREATMENT OF HEARING LOSS AND VERTIGO | AUDIOCURE PHARMA GMBH (DE) | 2013-01-31 | — | — | US | disclosed |
| WO-2011079841-A1 | BETA-CARBOLINES FOR USE IN THE TREATMENT OF HEARING LOSS AND VERTIGO | ROMMELSPACHER HANS (DE) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130028958-A1 | BETA-CARBOLINES FOR USE IN THE TREATMENT OF HEARING LOSS AND VERTIGO | CBFB, ADRA2B, SLC6A12 | MAOA 2170/4885MAOB 329/4885KDM4E 2553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.