Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.43 |
| ▸ | MAOA | P21397 | 3/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12464508 | 0.79 | MAOA (0.51) | HASPINROCK2MAOACHUKMAOB | |
| SCHEMBL1921708 | 0.78 | HASPIN (0.61) | HASPINROCK2DYRK1AMAOACHUK | |
| SCHEMBL2217482 | 0.77 | DYRK1A (0.66) | HASPINDYRK1AMAOAACHE | |
| SCHEMBL20147149 | 0.76 | MAOA (0.46) | HASPINROCK2MAOACHUKMAOB | |
| SCHEMBL4176158 | 0.76 | HASPIN (0.48) | HASPINROCK2DYRK1AMAOACHUK | |
| SCHEMBL16093621 | 0.74 | HASPIN (0.54) | HASPINROCK2DYRK1AMAOACHUK | |
| SCHEMBL4166596 | 0.74 | HASPIN (0.71) | HASPINROCK2DYRK1AMAOAMAOB | |
| SCHEMBL16099409 | 0.73 | HASPIN (0.59) | HASPINROCK2DYRK1AMAOAMAOB | |
| SCHEMBL28917849 | 0.73 | HASPIN (0.69) | HASPINROCK2DYRK1AMAOAMAOB | |
| SCHEMBL30939878 | 0.73 | HASPIN (0.59) | HASPINROCK2DYRK1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227619-A1 | Harmine derivatives, intermediates used in their preparations, preparation processes and use therefo | XINJIANG HUASHIDAN PHARMACEUTICAL RESEARCH CO., LTD. (CN) | 2009-09-10 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227619-A1 | Harmine derivatives, intermediates used in their preparations, preparation processes and use therefo | TPH1, HTR1F, TPH2 | HASPIN 467/4885ROCK2 1304/4885DYRK1A 2398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.