Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 6/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.38 |
| ▸ | CFD | P00746 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245335 | 0.89 | NR1H4 (0.50) | PPARDNR1H4FABP4 | |
| SCHEMBL1245294 | 0.88 | GPBAR1 (0.37) | SCN9AGPBAR1LMNASMN1; SMN2MEN1 | |
| SCHEMBL1245358 | 0.87 | NR1H4 (0.42) | PPARDNR1H4SCN9AGPBAR1FABP4 | |
| SCHEMBL3707308 | 0.87 | CFD (0.40) | PPARDCFDFABP4FABP5FFAR4 | |
| SCHEMBL1247132 | 0.87 | GPBAR1 (0.44) | GPBAR1LMNANPC1MEN1ALDH1A1 | |
| SCHEMBL1245176 | 0.86 | NR1H4 (0.40) | PPARDNR1H4SCN9AGPBAR1FABP4 | |
| SCHEMBL1247141 | 0.85 | GPBAR1 (0.37) | PPARDPPARGPPARANR1H4SCN9A | |
| SCHEMBL1246186 | 0.84 | PTGDR2 (0.38) | SCN9AGPBAR1MEN1ALDH1A1HPGD | |
| SCHEMBL1246477 | 0.84 | NR1H4 (0.42) | PPARDPPARGPPARANR1H4GPBAR1 | |
| SCHEMBL1247748 | 0.84 | SCN9A (0.39) | PPARDPPARGPPARANR1H4SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |