Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | FABP1 | P07148 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245358 | 0.90 | NR1H4 (0.42) | SCN9ANR1H4CYP2C19MAPTGPBAR1 | |
| SCHEMBL1245176 | 0.89 | NR1H4 (0.40) | SCN9ANR1H4CYP2C19MAPTGPBAR1 | |
| SCHEMBL1247097 | 0.88 | GABRA5 (0.44) | CYP2C19MAPTGPBAR1ALDH1A1POLB | |
| SCHEMBL1246477 | 0.87 | NR1H4 (0.42) | NR1H4MAPTGPBAR1PPARDALDH1A1 | |
| SCHEMBL1245335 | 0.87 | NR1H4 (0.50) | NR1H4MAPTPPARDFABP1FABP4 | |
| SCHEMBL3710544 | 0.87 | LPAR1 (0.42) | SCN9ANR1H4PPARDALDH1A1HPGD | |
| SCHEMBL1246467 | 0.85 | NR1H4 (0.43) | SCN9ANR1H4GPBAR1PPARDFABP1 | |
| SCHEMBL1246346 | 0.85 | SCN9A (0.38) | SCN9ANR1H4MAPTGPBAR1PPARD | |
| SCHEMBL1246914 | 0.85 | KDM4E (0.39) | SCN9ANR1H4GPBAR1PPARDPPARG | |
| SCHEMBL1246951 | 0.85 | CYP11B1 (0.40) | SCN9ANR1H4CYP2C19MAPTGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |