Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Zolmitriptan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D known ✓ | P28221 | 11/20 | 1.00 |
| ▸ | HTR1B known ✓ | P28222 | 11/20 | 1.00 |
| ▸ | HTR1A | P08908 | 10/20 | 1.00 |
| ▸ | HTR2A | P28223 | 5/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | HTR1F | P30939 | 2/20 | 0.63 |
| ▸ | HTR5A | P47898 | 4/20 | 0.54 |
| ▸ | HTR2C | P28335 | 3/20 | 0.54 |
| ▸ | HTR2B | P41595 | 2/20 | 0.54 |
| ▸ | HTR1E | P28566 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | HTR3A | P46098 | 1/20 | 0.54 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zolmitriptan SCHEMBL29835946 | 1.00 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL14861150 | 1.00 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL40595 | 1.00 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL29356689 | 1.00 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL33336 | 1.00 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL4427888 | 1.00 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL2377949 | 0.99 | HTR1D (0.98) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL2458156 | 0.99 | HTR1D (0.98) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL2540996 | 0.96 | HTR1D (0.92) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL2376692 | 0.95 | HTR1D (0.90) | HTR1DHTR1BHTR1AHTR2AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 174 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118095-B1 | A METHOD FOR THE PREPARATION OF ZOLMITRIPTAN | ZENTIVA KS (CZ) | 2010-11-03 | — | — | EP | claimed |
| US-20100145064-A1 | METHOD FOR THE PREPARATION OF ZOLMITRIPTAN | ZENTIVA K.S. (CZ) | 2010-06-10 | — | — | US | claimed |
| US-20100105919-A1 | METHOD FOR THE PREPARATION OF ZOLMITRIPTAN | ZENTIVA K.S. (CZ) | 2010-04-29 | — | — | US | claimed |
| EP-2125798-A2 | A METHOD FOR THE PREPARATION OF ZOLMITRIPTAN | Zentiva, k.s. (CZ) | 2009-12-02 | — | — | EP | claimed |
| WO-2008104134-A2 | A METHOD FOR THE PREPARATION OF ZOLMITRIPTAN | ZENTIVA, A.S. (CZ) | 2008-09-04 | — | — | WO | claimed |
| US-20070173536-A1 | Crystalline forms of zolmitriptan | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2007-07-26 | — | — | US | claimed |
| EP-1711493-A2 | CRYSTALLINE FORMS OF ZOLMITRIPTAN | CIBA SPECIALTY CHEMICALS HOLDING INC. Patent Departement (CH) | 2006-10-18 | — | — | EP | claimed |
| WO-2005075467-A2 | CRYSTALLINE FORMS OF ZOLMITRIPTAN | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2005-08-18 | — | — | WO | claimed |
| EP-0636623-B1 | Indole derivatives as 5-HT1- like agonists | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | claimed |
| US-6160123-A | One pot synthesis of 2-oxazolidinone derivatives | ZENECA, LTD. (GB) | 2000-12-12 | — | — | US | claimed |
| EP-0843672-A1 | ONE POT SYNTHESIS OF 2-OXAZOLIDINONE DERIVATIVES | ZENECA LIMITED (GB) | 1998-05-27 | — | — | EP | claimed |
| EP-0486666-B1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | ZENECA LTD (GB) | 1997-08-13 | — | — | EP | claimed |
| WO-1997006162-A1 | ONE POT SYNTHESIS OF 2-OXAZOLIDINONE DERIVATIVES | ZENECA LIMITED (GB) | 1997-02-20 | — | — | WO | claimed |
| WO-1996041633-A1 | METHODS OF TREATING COLD AND ALLERGIC RHINITIS | ELI LILLY AND COMPANY (US) | 1996-12-27 | — | — | WO | claimed |
| EP-0747049-A1 | Use of tachykinin antagonists in combination with serotonin agonists or serotonin reuptake inhibitors for the manufacture of a medicament for the treatment of allergic rhinitis | ELI LILLY AND COMPANY (US) | 1996-12-11 | — | — | EP | claimed |
| WO-1996029074-A1 | METHODS OF TREATING OR PREVENTING PAIN OR NOCICEPTION | ELI LILLY AND COMPANY (US) | 1996-09-26 | — | — | WO | claimed |
| EP-0710479-A1 | Use of a serotonin agonist in combination with a tachykinin receptor antagonist for the manufacture of a medicament for the treatment or prevention of migraine | ELI LILLY AND COMPANY (US) | 1996-05-08 | — | — | EP | claimed |
| WO-1996011000-A1 | METHODS OF TREATING MIGRAINE | ELI LILLY AND COMPANY (US) | 1996-04-18 | — | — | WO | claimed |
| US-5466699-A | Indolyl compounds for treating migraine | BURROUGHS WELLCOME CO. (US) | 1995-11-14 | — | — | US | claimed |
| EP-0636623-A1 | Indole derivatives as 5-HT1- like agonists | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-02-01 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105919-A1 | METHOD FOR THE PREPARATION OF ZOLMITRIPTAN | SOST, SFRP1, FZD7 | HTR1D 9/4885HTR1B 44/4885HTR1A 116/4885 |
| US-20070173536-A1 | Crystalline forms of zolmitriptan | LIPA, LPXN, CETP | HTR1D 29/4885HTR1B 120/4885HTR1A 82/4885 |
| US-20100145064-A1 | METHOD FOR THE PREPARATION OF ZOLMITRIPTAN | LPXN, TREH, HTR3A | HTR1D 148/4885HTR1B 191/4885HTR1A 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.