Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14813751 | 0.90 | MAPT (0.39) | MAPTPIN1HPGDKDM4EBCAT2 | |
| SCHEMBL12466650 | 0.80 | TXNRD1 (0.40) | MAPTPIN1HPGDKDM4EBCAT2 | |
| SCHEMBL12466747 | 0.72 | MAPT (0.37) | MAPTPIN1HPGDKDM4EBCAT2 | |
| SCHEMBL7119630 | 0.69 | MEN1 (0.41) | MAPTPIN1HPGDKDM4EL3MBTL1 | |
| SCHEMBL6747115 | 0.67 | POLB (0.57) | MAPTKDM4ELMNAL3MBTL1ATM | |
| SCHEMBL27072915 | 0.65 | CALM1 (0.55) | LMNAL3MBTL1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL15559635 | 0.65 | VCAM1 (0.36) | MAPTHPGDKDM4ECYP2C9LMNA | |
| SCHEMBL7116983 | 0.64 | KMT2A (0.50) | MAPTKDM4EATMNPC1RAB9A | |
| SCHEMBL14431892 | 0.64 | HPGD (0.45) | MAPTHPGDKDM4ECYP2C9GAA | |
| SCHEMBL4438379 | 0.64 | CRHBP (0.49) | MAPTPIN1HPGDKDM4ECYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668184-A1 | DERIVATIVES OF AZAINDAZOLE OR DIAZAINDAZOLE TYPE AS MEDICAMENT | Pierre Fabre Medicament (FR) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101239-A1 | DERIVATIVES OF AZAINDAZOLE OR DIAZAINDAZOLE TYPE AS MEDICAMENT | PIERRE FABRE MEDICAMENT (FR) | 2012-08-02 | — | — | WO | disclosed |