Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.62 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.52 |
| ▸ | MIF | P14174 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.49 |
| ▸ | FNTA | P49354 | 2/20 | 0.48 |
| ▸ | FNTB | P49356 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PRNP | P04156 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2549837 | 0.86 | AKR1C3 (0.59) | NR4A1SRD5A2AKR1C3ALOX15PRNP | |
| SCHEMBL1820530 | 0.83 | NR4A1 (0.66) | NR4A1SRD5A2AKR1C3FNTAFNTB | |
| SCHEMBL4801729 | 0.80 | NR4A1 (0.62) | NR4A1SRD5A2AKR1C3FNTAFNTB | |
| SCHEMBL29583954 | 0.80 | NR4A1 (0.62) | NR4A1SRD5A2AKR1C3FNTAFNTB | |
| SCHEMBL1821327 | 0.80 | NR4A1 (0.62) | NR4A1SRD5A2AKR1C3FNTAFNTB | |
| SCHEMBL4551433 | 0.80 | NR4A1 (0.62) | NR4A1SRD5A2AKR1C3FNTAFNTB | |
| SCHEMBL9281265 | 0.79 | NR4A1 (0.65) | NR4A1SRD5A2MIFAKR1C3TP53 | |
| SCHEMBL29928911 | 0.79 | NR4A1 (0.65) | NR4A1SRD5A2MIFAKR1C3TP53 | |
| SCHEMBL241422 | 0.78 | PRNP (0.56) | NR4A1AKR1C3TSHRALOX15PRNP | |
| SCHEMBL29540504 | 0.78 | PRNP (0.56) | NR4A1AKR1C3TSHRALOX15PRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140051689-A1 | Polycyclic Agents for the Treatment of Respiratory Syncytial Virus Infections | BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) | 2014-02-20 | — | — | US | disclosed |
| US-8598193-B2 | Polycyclic agents for the treatment of respiratory syncytial virus infections | BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) | 2013-12-03 | — | — | US | disclosed |
| EP-2287167-A1 | Polycyclic agents for the treatment of respiratory syncytial virus infections | BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) | 2011-02-23 | — | — | EP | disclosed |
| EP-1697377-A4 | POLYCYCLIC AGENTS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTIONS | BIOTA SCIENT MANAGEMENT (AU) | 2008-03-19 | — | — | EP | disclosed |
| US-20070287700-A1 | Polycyclic agents for the treatment of respiratory syncytial virus infections | BIOTA SCIENTFIC MANAGEMENMT PTY LTD. (AU) | 2007-12-13 | — | — | US | disclosed |
| EP-1697377-A1 | POLYCYCLIC AGENTS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTIONS | BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061513-A1 | POLYCYCLIC AGENTS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTIONS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051689-A1 | Polycyclic Agents for the Treatment of Respiratory Syncytial Virus Infections | SDHA, SDHB, NDUFB7 | NR4A1 321/4885SRD5A2 1196/4885MIF 4501/4885 |
| US-20070287700-A1 | Polycyclic agents for the treatment of respiratory syncytial virus infections | PAICS, SDHB, SDHA | NR4A1 242/4885SRD5A2 1499/4885MIF 4647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.