Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.58 |
| ▸ | JAK3 | P52333 | 2/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.58 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
| ▸ | CCND1 | P24385 | 2/20 | 0.47 |
| ▸ | CCND2 | P30279 | 2/20 | 0.47 |
| ▸ | CCND3 | P30281 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 7/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | KIF5B | P33176 | 2/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7754110 | 0.86 | EGFR (0.54) | ABCG2JAK3ABCB1CDK4CCND1 | |
| SCHEMBL360021 | 0.83 | EGFR (0.53) | JAK3EGFRBRAFKDM4EALDH1A1 | |
| SCHEMBL7799220 | 0.80 | ABCG2 (0.65) | ABCG2EGFRBRAFKDM4EKDR | |
| SCHEMBL7753469 | 0.80 | FGFR1 (0.56) | ABCG2ABCB1EGFRBRAFKDR | |
| SCHEMBL2205050 | 0.79 | KDM4E (0.52) | ABCG2EGFRKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7801861 | 0.78 | KDM4E (0.55) | ABCG2EGFRBRAFKDM4EALDH1A1 | |
| SCHEMBL8812882 | 0.78 | PDGFRB (0.57) | CDK4CCND1EGFRBRAFKDM4E | |
| SCHEMBL1571331 | 0.78 | PDE5A (0.57) | EGFRKDRMAPTCDK1CDK2 | |
| SCHEMBL7595199 | 0.78 | PDGFRB (0.43) | JAK3EGFRBRAFKDM4EALDH1A1 | |
| SCHEMBL7757002 | 0.78 | PDGFRB (0.59) | CDK4CCND1EGFRBRAFKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2830625-A1 | INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR INHIBITORS | Merck Sharp & Dohme Corporation (US) | 2015-02-04 | — | — | EP | disclosed |
| WO-2013148227-A1 | INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-10-03 | — | — | WO | disclosed |
| EP-2632472-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058210-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |
| EP-2278969-A2 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2010011375-A2 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2010-01-28 | — | — | WO | disclosed |
| EP-2129778-A1 | SITE-SPECIFIC ENZYMATIC DEPOSITION OF METAL IN SITU | Nanoprobes, Inc. (US) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008109617-A1 | SITE-SPECIFIC ENZYMATIC DEPOSITION OF METAL IN SITU | NANOPROBES, INC. (US) | 2008-09-12 | — | — | WO | disclosed |
| EP-1162974-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-1999061428-A9 | QUINAZOLINES FOR TREATING BRAIN TUMOR | PARKER HUGHES INST (US) | 2001-10-04 | — | — | WO | disclosed |
| EP-1082311-A1 | QUINAZOLINES FOR TREATING BRAIN TUMOR | Parker Hughes Institute (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-2000056338-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |
| WO-1999061428-A1 | QUINAZOLINES FOR TREATING BRAIN TUMOR | PARKER HUGHES INSTITUTE (US) | 1999-12-02 | — | — | WO | disclosed |