Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971530 | 0.79 | TP53 (0.50) | ALDH1A1TSHRGLAKDM4EMAPK14 | |
| SCHEMBL9911042 | 0.76 | ADORA2A (0.43) | DRD2HTR1AADORA2AADORA1AKT1 | |
| Propionic Acid SCHEMBL2687317 | 0.75 | DRD2 (0.40) | DRD2HTR1AADORA2AADORA1AKT1 | |
| Propionic Acid SCHEMBL2686240 | 0.74 | NOTUM (0.41) | DRD2HTR1AADORA2AADORA1AKT1 | |
| Propionic Acid SCHEMBL2637824 | 0.74 | ADORA2A (0.45) | DRD2HTR1AADORA2AADORA1AKT1 | |
| SCHEMBL10748058 | 0.73 | HPGD (0.41) | ALDH1A1TSHRGLAKDM4EMAPT | |
| SCHEMBL1340046 | 0.72 | ALOX5 (0.40) | DRD2HTR1AADORA2AADORA1AKT1 | |
| SCHEMBL18665582 | 0.71 | KDM4E (0.43) | DRD2HTR1AADORA2AADORA1AKT1 | |
| SCHEMBL1612190 | 0.70 | TSHR (0.49) | ALDH1A1TSHRMAPTGAAHSD17B10 | |
| SCHEMBL1549847 | 0.70 | ADRA1D (0.43) | ADORA2AADORA1AKT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459572-A2 | SPIROCYCLIC AMIDE DERIVATIVES | AstraZeneca AB (SE) | 2012-06-06 | — | — | EP | disclosed |
| WO-2011012896-A2 | COMPOUNDS - 801 | ASTRAZENECA AB (SE) | 2011-02-03 | — | — | WO | disclosed |