Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31170829 | 0.85 | DRD2 (0.39) | NOTUMHTR1ADRD2PTGER3EGFR | |
| Propionic Acid SCHEMBL2687317 | 0.84 | DRD2 (0.40) | HTR1ADRD2ADORA2AADORA1AKT1 | |
| Propionic Acid SCHEMBL2637824 | 0.83 | ADORA2A (0.45) | HTR1ADRD2ADORA2AADORA1AKT1 | |
| SCHEMBL9911042 | 0.77 | ADORA2A (0.43) | HTR1ADRD2ADORA2AADORA1AKT1 | |
| SCHEMBL1246796 | 0.74 | DRD2 (0.36) | HTR1ADRD2ADORA2AADORA1AKT1 | |
| SCHEMBL1340046 | 0.73 | ALOX5 (0.40) | HTR1ADRD2ADORA2AADORA1AKT1 | |
| SCHEMBL18665582 | 0.72 | KDM4E (0.43) | NOTUMHTR1ADRD2ADORA2AADORA1 | |
| SCHEMBL1549847 | 0.71 | ADRA1D (0.43) | ADORA2AADORA1AKT1KMT2A | |
| SCHEMBL1612190 | 0.71 | TSHR (0.49) | KMT2A | |
| SCHEMBL305910 | 0.71 | ADORA2A (0.46) | HTR1ADRD2ADORA2AADORA1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438050-B9 | NOVEL DERIVATIVES OF ARYL-{4-HALOGENO-4-[AMINOMETHYL]-PIPERIDIN-1-YL}-METHANONE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS | PF MEDICAMENT (FR) | 2014-04-23 | — | — | EP | disclosed |
| US-8669250-B2 | Derivatives of aryl-{4-halogeno-4-[aminomethyl]-piperidin-1-yl}-methanone, their method of preparation and their use as medicinal products | PIERRE FABRE MEDICAMENT (FR) | 2014-03-11 | — | — | US | disclosed |
| EP-2438050-B1 | NOVEL DERIVATIVES OF ARYL-{4-HALOGENO-4-[AMINOMETHYL]-PIPERIDIN-1-YL}-METHANONE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS | PF MEDICAMENT (FR) | 2013-08-07 | — | — | EP | disclosed |
| US-20120115860-A1 | NOVEL DERIVATIVES OF ARYL--METHANONE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS | PIERRE FABRE MEDICAMENT (FR) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115860-A1 | NOVEL DERIVATIVES OF ARYL--METHANONE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS | CYP11B1, CYP11B2, CYP3A43 | NOTUM 2647/4885HTR1A 388/4885DRD2 3005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.