Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.44 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.44 |
| ▸ | MCL1 known ✓ | Q07820 | 1/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 10/20 | 0.44 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SNCA | P37840 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29557697 | 1.00 | NOX1 (0.44) | NOX1GAAMAPTMEN1ALOX15 | |
| SCHEMBL149995 | 0.88 | NOX1 (0.57) | NOX1GAAMAPTMEN1ALOX15 | |
| SCHEMBL29390811 | 0.88 | NOX1 (0.57) | NOX1GAAMAPTMEN1ALOX15 | |
| Hydrochloric Acid SCHEMBL29850528 | 0.86 | NOX1 (0.55) | NOX1GAAMAPTMEN1ALOX15 | |
| Phenothiazine SCHEMBL31210229 | 0.81 | NOX1 (0.68) | NOX1GAAMAPTMEN1ALOX15 | |
| Thiosulfuric Acid SCHEMBL18553810 | 0.78 | NOX1 (0.46) | NOX1GAAMAPTMEN1ALOX15 | |
| SCHEMBL16815268 | 0.77 | NOX1 (0.52) | NOX1GAAMAPTMEN1ALOX15 | |
| SCHEMBL21101750 | 0.77 | NOX1 (0.52) | NOX1GAAMAPTMEN1ALOX15 | |
| Phenothiazine SCHEMBL38662173 | 0.74 | NOX1 (0.74) | NOX1GAAMAPTMEN1ALOX15 | |
| SCHEMBL88106 | 0.73 | NOX1 (0.59) | NOX1GAAMAPTMEN1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180464-B2 | Phenothiazine diaminium salts and their use | WISTA LABORATORIES LTD. (SG) | 2021-11-23 | — | — | US | disclosed |
| US-10864216-B2 | Phenothiazine diaminium salts and their use | WISTA LABORATORIES, LTD. (SG) | 2020-12-15 | — | — | US | disclosed |
| US-20200246350-A1 | PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE | WISTA LABORATORIES LTD. (SG) | 2020-08-06 | — | — | US | disclosed |
| US-20190046537-A1 | PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE | WISTA LABORATORIES LTD. (SG) | 2019-02-14 | — | — | US | disclosed |
| US-9907804-B2 | Phenothiazine diaminium salts and their use | WISTA LABORATORIES LTD. (SG) | 2018-03-06 | — | — | US | disclosed |
| US-20160237048-A1 | PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE | WISTA LABORATORIES LTD. (SG) | 2016-08-18 | — | — | US | disclosed |
| US-9283230-B2 | Phenothiazine diaminium salts and their use | WISTA LABORATORIES LTD. (SG) | 2016-03-15 | — | — | US | disclosed |
| EP-2673266-A1 | PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE | WisTa Laboratories Ltd. (SG) | 2013-12-18 | — | — | EP | disclosed |
| US-20130315992-A1 | PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE | WISTA LABORATORIES LIMITED (SG) | 2013-11-28 | — | — | US | disclosed |
| WO-2012107706-A1 | PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE | WISTA LABORATORIES LTD. (SG) | 2012-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130315992-A1 | PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE | PSEN1, H1-10, HRH4 | SLC6A2 285/4885HTR2C 1258/4885SLC6A3 49/4885 |
| US-11180464-B2 | Phenothiazine diaminium salts and their use | QDPR, SLC35A1, SLC6A7 | SLC6A2 13/4885HTR2C 470/4885SLC6A3 14/4885 |
| US-20160237048-A1 | PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE | QDPR, SLC35A1, SLC6A7 | SLC6A2 13/4885HTR2C 470/4885SLC6A3 14/4885 |
| US-20200246350-A1 | PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE | QDPR, SLC35A1, SLC6A7 | SLC6A2 13/4885HTR2C 470/4885SLC6A3 14/4885 |
| US-10864216-B2 | Phenothiazine diaminium salts and their use | QDPR, SLC35A1, SLC6A7 | SLC6A2 13/4885HTR2C 470/4885SLC6A3 14/4885 |
| US-20190046537-A1 | PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE | QDPR, SLC35A1, SLC6A7 | SLC6A2 13/4885HTR2C 470/4885SLC6A3 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.