Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.57 |
| ▸ | NPY4R | P50391 | 6/20 | 0.52 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.52 |
| ▸ | NPY1R | P25929 | 4/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | NPY2R | P49146 | 2/20 | 0.48 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.48 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.48 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | CPA1 | P15085 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12470794 | 1.00 | ACE (0.57) | ACENPY4RNPY5RNPY1ROPRD1 | |
| SCHEMBL15328426 | 0.94 | ACE (0.62) | ACENPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL15328423 | 0.94 | ACE (0.62) | ACENPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL30445690 | 0.89 | MME (0.60) | ACEOPRD1OPRM1OPRK1MME | |
| SCHEMBL2549533 | 0.89 | MME (0.60) | ACEOPRD1OPRM1OPRK1MME | |
| SCHEMBL29655902 | 0.88 | CTRB1 (0.57) | ACEOPRD1OPRM1OPRK1ERAP2 | |
| SCHEMBL17074558 | 0.87 | NPY5R (0.55) | ACENPY4RNPY5RNPY1ROPRD1 | |
| SCHEMBL17074565 | 0.87 | NPY5R (0.55) | ACENPY4RNPY5RNPY1ROPRD1 | |
| SCHEMBL15044546 | 0.84 | ACE (0.63) | ACENPY4RNPY5RNPY1RNPY2R | |
| Casokefamide SCHEMBL1373200 | 0.84 | OPRD1 (0.69) | OPRD1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169295-B2 | Macrocycles and macrocycle stabilized peptides | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-10-27 | — | — | US | disclosed |
| EP-2627662-B1 | METHODS FOR PREPARING MACROCYCLES AND MACROCYCLE STABILIZED PEPTIDES | BRISTOL MYERS SQUIBB CO (US) | 2015-09-16 | — | — | EP | disclosed |
| US-20130281657-A1 | MACROCYCLES AND MACROCYCLE STABILIZED PEPTIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-10-24 | — | — | US | disclosed |
| EP-2627662-A1 | METHODS FOR PREPARING MACROCYCLES AND MACROCYCLE STABILIZED PEPTIDES | Bristol-Myers Squibb Company (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012051405-A1 | METHODS FOR PREPARING MACROCYCLES AND MACROCYCLE STABILIZED PEPTIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130281657-A1 | MACROCYCLES AND MACROCYCLE STABILIZED PEPTIDES | PTMS, VIP, MTPN | ACE 1283/4885NPY4R 474/4885NPY5R 523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.