Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL228596 | 0.87 | NR4A1 (0.47) | NR4A1NR4A2NR4A3EGFRKDR | |
| SCHEMBL26134757 | 0.84 | ALDH1A1 (0.46) | NR4A1NR4A2NR4A3EGFRKDR | |
| SCHEMBL12475214 | 0.81 | NR4A1 (0.45) | NR4A1NR4A2NR4A3EGFRKDR | |
| SCHEMBL11794625 | 0.76 | NR4A1 (0.61) | NR4A1NR4A2NR4A3CDC25BMEN1 | |
| SCHEMBL6614659 | 0.75 | ADORA2A (0.49) | EGFRKDRKMT2AHSD17B10ALDH1A1 | |
| SCHEMBL2228819 | 0.74 | SMN1; SMN2 (0.47) | EGFRKDRALDH1A1KDM4EHPGD | |
| SCHEMBL30632058 | 0.74 | SMN1; SMN2 (0.47) | EGFRKDRALDH1A1KDM4EHPGD | |
| SCHEMBL2541660 | 0.74 | LMNA (0.40) | NR4A1NR4A2NR4A3EGFRKDR | |
| SCHEMBL17744802 | 0.72 | G6PD (0.61) | NR4A1NR4A2NR4A3MEN1KMT2A | |
| SCHEMBL9851131 | 0.72 | G6PD (0.65) | NR4A1NR4A2NR4A3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616443-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | Exelixis, Inc. (US) | 2013-07-24 | — | — | EP | claimed |
| WO-2012037132-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | claimed |