Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Flumazenil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 known ✓ | P18507 | 16/20 | 0.98 |
| ▸ | GABRB3 known ✓ | P28472 | 16/20 | 0.98 |
| ▸ | GABRA5 known ✓ | P31644 | 16/20 | 0.98 |
| ▸ | GABRA1 known ✓ | P14867 | 15/20 | 0.98 |
| ▸ | GABRA3 known ✓ | P34903 | 14/20 | 0.98 |
| ▸ | GABRA2 known ✓ | P47869 | 14/20 | 0.98 |
| ▸ | GABRA6 known ✓ | Q16445 | 10/20 | 0.98 |
| ▸ | GABRB2 known ✓ | P47870 | 8/20 | 0.98 |
| ▸ | GABRA4 known ✓ | P48169 | 4/20 | 0.98 |
| ▸ | GABRP known ✓ | O00591 | 1/20 | 0.98 |
| ▸ | GABRD known ✓ | O14764 | 1/20 | 0.98 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.98 |
| ▸ | GABRE known ✓ | P78334 | 1/20 | 0.98 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 1/20 | 0.98 |
| ▸ | GABRG3 known ✓ | Q99928 | 1/20 | 0.98 |
| ▸ | GABRQ known ✓ | Q9UN88 | 1/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.98 |
| ▸ | MEN1 | O00255 | 1/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flumazenil SCHEMBL11885881 | 0.99 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| Flumazenil SCHEMBL29746432 | 0.99 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| Flumazenil SCHEMBL5781309 | 0.99 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| Flumazenil SCHEMBL30305657 | 0.99 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| Flumazenil SCHEMBL79030 | 0.99 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| Flumazenil SCHEMBL16187025 | 0.99 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| Flumazenil SCHEMBL29444064 | 0.99 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| Flumazenil SCHEMBL29085132 | 0.96 | GABRG2 (0.94) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| Flumazenil SCHEMBL29025825 | 0.93 | GABRG2 (0.88) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL16479000 | 0.91 | GABRG2 (0.85) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678320-B1 | FLUMAZENIL COMPLEXES, COMPOSITIONS COMPRISING SAME AND USES THEREOF | COERULEUS LTD (IL) | 2018-09-19 | — | — | EP | disclosed |
| US-9585893-B2 | Flumazenil complexes, compositions comprising same and uses thereof | COERULEUS LTD. (IL) | 2017-03-07 | — | — | US | disclosed |
| CN-103502224-A | Flumazenil complexes, compositions comprising same and uses thereof | COERULEUS LTD | 2014-01-08 | — | — | CN | disclosed |
| US-20130345202-A1 | Flumazenil Complexes, Compositions Comprising Same And Uses Thereof | COERULEUS LTD. (IL) | 2013-12-26 | — | — | US | disclosed |
| WO-2012114342-A1 | FLUMAZENIL COMPLEXES, COMPOSITIONS COMPRISING SAME AND USES THEREOF | COERULEUS LTD. (IL) | 2012-08-30 | — | — | WO | disclosed |
| CN-102389432-A | Compound antagonist of animal anesthetic and application of compound antagonist | UNIV NANJING AGRICULTURAL | 2012-03-28 | — | — | CN | disclosed |