Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Flumazenil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 known ✓ | P18507 | 16/20 | 1.00 |
| ▸ | GABRB3 known ✓ | P28472 | 16/20 | 1.00 |
| ▸ | GABRA5 known ✓ | P31644 | 16/20 | 1.00 |
| ▸ | GABRA1 known ✓ | P14867 | 15/20 | 1.00 |
| ▸ | GABRA3 known ✓ | P34903 | 14/20 | 1.00 |
| ▸ | GABRA2 known ✓ | P47869 | 14/20 | 1.00 |
| ▸ | GABRA6 known ✓ | Q16445 | 10/20 | 1.00 |
| ▸ | GABRB2 known ✓ | P47870 | 8/20 | 1.00 |
| ▸ | GABRA4 known ✓ | P48169 | 4/20 | 1.00 |
| ▸ | GABRP known ✓ | O00591 | 1/20 | 1.00 |
| ▸ | GABRD known ✓ | O14764 | 1/20 | 1.00 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 1.00 |
| ▸ | GABRE known ✓ | P78334 | 1/20 | 1.00 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 1/20 | 1.00 |
| ▸ | GABRG3 known ✓ | Q99928 | 1/20 | 1.00 |
| ▸ | GABRQ known ✓ | Q9UN88 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flumazenil SCHEMBL5781309 | 1.00 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| Flumazenil SCHEMBL29444064 | 1.00 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| Flumazenil SCHEMBL11885881 | 1.00 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| Flumazenil SCHEMBL79030 | 1.00 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| Flumazenil SCHEMBL30305657 | 1.00 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| Flumazenil SCHEMBL16187025 | 1.00 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| Flumazenil SCHEMBL12484498 | 0.99 | GABRG2 (0.98) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| Flumazenil SCHEMBL29085132 | 0.97 | GABRG2 (0.94) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| Flumazenil SCHEMBL29025825 | 0.94 | GABRG2 (0.88) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL16479000 | 0.92 | GABRG2 (0.85) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12292437-B2 | Fluorescence histo-tomography (FHT) systems and methods | EMIT IMAGING, INC. (US) | 2025-05-06 | — | — | US | disclosed |
| CN-119095628-A | PET tracers for visualizing GABAA gamma 1 receptors | 豪夫迈·罗氏有限公司 | 2024-12-06 | — | — | CN | disclosed |
| US-12078625-B2 | System and method for high-throughput radio thin layer chromatography analysis | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-09-03 | — | — | US | disclosed |
| CN-112094259-B | Iodine (III) -mediated radiofluorination | 通用医疗公司 | 2023-09-01 | — | — | CN | disclosed |
| US-20220341916-A1 | FLUORESCENCE HISTO-TOMOGRAPHY (FHT) SYSTEMS AND METHODS | EMIT IMAGING, INC. | 2022-10-27 | — | — | US | disclosed |
| US-20220244228-A1 | SYSTEM AND METHOD FOR HIGH-THROUGHPUT RADIO THIN LAYER CHROMATOGRAPHY ANALYSIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-08-04 | — | — | US | disclosed |
| US-11385222-B2 | Fluorescence histo-tomography (FHT) systems and methods | EMIT IMAGING, INC. (US) | 2022-07-12 | — | — | US | disclosed |