Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2727337 | 0.94 | ALDH1A1 (0.42) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL7603424 | 0.78 | SLC9A1 (0.38) | ALDH1A1GAASLC9A1LMNAMAPT | |
| SCHEMBL9597914 | 0.77 | APOBEC3G (0.44) | ALDH1A1KDM4EGAAKMT2AHPGD | |
| SCHEMBL16919064 | 0.72 | ALDH1A1 (0.40) | ALDH1A1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL11475505 | 0.71 | KDM4E (0.41) | ALDH1A1KDM4EGAAGFERPLK1 | |
| SCHEMBL16325249 | 0.71 | SLC9A1 (0.38) | ALDH1A1KDM4EGAAKMT2ASLC9A1 | |
| SCHEMBL18713930 | 0.69 | SLC9A1 (0.39) | ALDH1A1KDM4EGAAKMT2ASLC9A1 | |
| SCHEMBL16371576 | 0.68 | HTT (0.37) | ALDH1A1KDM4EGAAKMT2ASLC9A1 | |
| SCHEMBL10361179 | 0.68 | MAPK10 (0.35) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL7573998 | 0.67 | SLC9A1 (0.34) | ALDH1A1KDM4EGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879893-B2 | Zinc binding ligand; sustained release of insulin | NOVO NORDISK A/S (DK) | 2011-02-01 | — | — | US | disclosed |
| US-20090123563-A1 | Pharmaceutical Preparations Comprising Insulin, Zinc Ions and Zinc-Binding Ligand | NOVO NORDISK A/S (DK) | 2009-05-14 | — | — | US | disclosed |
| EP-1585541-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING INSULIN AND LEGENDS OF INSULIN HEXAMER | NOVO NORDISK AS (DK) | 2007-11-14 | — | — | EP | disclosed |
| EP-1429763-B1 | NOVEL LIGANDS FOR THE HisB10 Zn2+ SITES OF THE R-STATE INSULIN HEXAMER | NOVO NORDISK AS (DK) | 2007-05-30 | — | — | EP | disclosed |
| EP-1768694-A1 | PHAMACEUTICAL PREPARATIONS COMPRISING INSULIN | NOVO NORDISK A/S (DK) | 2007-04-04 | — | — | EP | disclosed |
| US-20060258561-A1 | Novel NPH insulin preparations | NOVO NORDISK A/S (DK) | 2006-11-16 | — | — | US | disclosed |
| WO-2006082245-A1 | PHARMACEUTICAL PREPARATIONS COMPRISING INSULIN, ZINC IONS AND A ZINC-BINDING LIGAND | NOVO NORDISK A/S (DK) | 2006-08-10 | — | — | WO | disclosed |
| US-20060069013-A1 | Pharmaceutical preparations comprising acid-stabilised insulin | NOVO NORDISK A/S (DK) | 2006-03-30 | — | — | US | disclosed |
| WO-2006005683-A1 | PHAMACEUTICAL PREPARATIONS COMPRISING INSULIN | NOVO NORDISK A/S (DK) | 2006-01-19 | — | — | WO | disclosed |
| EP-1610812-A1 | PHARMACEUTICAL PREPARATIONS COMPRISING ACID-STABILISED INSULIN | NOVO NORDISK A/S (DK) | 2006-01-04 | — | — | EP | disclosed |
| US-20030229120-A1 | Novel ligands for the hisb10 zn2+ sites of the r-state insulin hexamer | NOVO NORDISK A/S (DK) | 2003-12-11 | — | — | US | disclosed |
| WO-2003027081-A2 | NOVEL LIGANDS FOR THE HisB10 Zn2+ SITES OF THE R-STATE INSULIN HEXAMER | NOVO NORDISK A/S (DK) | 2003-04-03 | — | — | WO | disclosed |
| EP-0643049-B1 | A process for the preparation of 1-substituted-5(4H)-tetrazolinones | BAYER AGROCHEM KK (JP) | 1997-05-14 | — | — | EP | disclosed |
| EP-0759919-A1 | NEW AZOLIDINEDIONES AS ANTIHYPERGLYCEMIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-03-05 | — | — | EP | disclosed |
| US-5502204-A | REACTING WITH ETHYLENE OXIDE DERIVATIVE | NIHON BAYER AGROCHEM K.K. (JP) | 1996-03-26 | — | — | US | disclosed |
| EP-0643049-A1 | A process for the preparation of 1-substituted-5(4H)-tetrazolinones | NIHON BAYER AGROCHEM K.K. (JP) | 1995-03-15 | — | — | EP | disclosed |
| US-4868321-A | FOR HERBICIDES | FMC CORPORATION (US) | 1989-09-19 | — | — | US | disclosed |
| EP-0252982-A4 | HERBICIDAL 1-ARYL-4-SUSTITUTTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF. | FMC CORP (US) | 1988-08-17 | — | — | EP | disclosed |
| EP-0252982-A1 | HERBICIDAL 1-ARYL-4-SUSTITUTTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF | FMC Corporation (US) | 1988-01-20 | — | — | EP | disclosed |
| WO-1987003873-A1 | HERBICIDAL 1-ARYL-4-SUBSTITUTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF | FMC CORPORATION (US) | 1987-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060258561-A1 | Novel NPH insulin preparations | IAPP, HBB, INSR | ALDH1A1 4866/4885KDM4E 4791/4885GAA 2116/4885 |
| US-20060069013-A1 | Pharmaceutical preparations comprising acid-stabilised insulin | IAPP, GPR119, INSR | ALDH1A1 4795/4885KDM4E 4773/4885GAA 1232/4885 |
| US-20030229120-A1 | Novel ligands for the hisb10 zn2+ sites of the r-state insulin hexamer | IAPP, IRS1, GPR119 | ALDH1A1 4873/4885KDM4E 4783/4885GAA 3054/4885 |
| US-20090123563-A1 | Pharmaceutical Preparations Comprising Insulin, Zinc Ions and Zinc-Binding Ligand | IAPP, IRS1, HBB | ALDH1A1 4836/4885KDM4E 4599/4885GAA 3170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.