Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.59 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.59 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.59 |
| ▸ | DRD1 | P21728 | 2/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | HRH1 | P35367 | 2/20 | 0.59 |
| ▸ | HTR2B | P41595 | 2/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5319116 | 0.91 | MEN1 (0.54) | OPRM1DRD3CYP2D6CHRM2CHRM4 | |
| SCHEMBL172597 | 0.86 | KMT2A (0.62) | OPRM1DRD3CYP2D6CHRM2CHRM4 | |
| SCHEMBL16227208 | 0.83 | CYP2D6 (0.67) | CYP2D6CHRM2CHRM1KCNA3ALDH1A1 | |
| SCHEMBL8371746 | 0.82 | OPRM1 (0.59) | OPRM1DRD3CYP2D6CHRM2CHRM4 | |
| SCHEMBL1491229 | 0.82 | OPRD1 (0.65) | OPRM1DRD3CYP2D6CHRM2CHRM4 | |
| SCHEMBL4249388 | 0.82 | LMNA (0.60) | OPRM1DRD3CYP2D6CHRM2CHRM4 | |
| SCHEMBL8371748 | 0.82 | OPRD1 (0.67) | OPRM1DRD3CYP2D6CHRM2CHRM4 | |
| SCHEMBL7381083 | 0.82 | DRD3 (0.60) | OPRM1DRD3CYP2D6CHRM2CHRM4 | |
| SCHEMBL7963339 | 0.82 | DRD3 (0.59) | OPRM1DRD3CYP2D6CHRM2CHRM4 | |
| SCHEMBL7650625 | 0.81 | OPRM1 (0.54) | OPRM1DRD3CYP2D6CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2654726-A1 | SOLID DISPERSION FORMULATIONS AND METHODS OF USE THEREOF | Zalicus Pharmaceuticals Ltd. (CA) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012122279-A1 | SOLID DISPERSION FORMULATIONS AND METHODS OF USE THEREOF | ZALICUS PHARMACEUTICALS LTD. (CA) | 2012-09-13 | — | — | WO | disclosed |