Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GPR3 | P46089 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | F12 | P00748 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12527287 | 0.80 | GPR3 (0.41) | KDM4EGPR3ACHEBCHEHSD17B10 | |
| SCHEMBL28301397 | 0.74 | KDM4E (0.50) | KDM4EGPR3ACHEF12PLAU | |
| SCHEMBL29127161 | 0.73 | ALDH1A1 (0.45) | ACHEBCHEF12PLAUNCF1 | |
| SCHEMBL12491150 | 0.72 | PLAU (0.44) | KDM4EGPR3ACHEBCHEF12 | |
| SCHEMBL7258713 | 0.71 | KDM4E (0.47) | KDM4EGPR3ACHEF12PLAU | |
| SCHEMBL15401178 | 0.71 | KDM4E (0.47) | KDM4EGPR3ACHEF12PLAU | |
| SCHEMBL558613 | 0.71 | KDM4E (0.47) | KDM4EGPR3ACHEF12PLAU | |
| SCHEMBL12490240 | 0.71 | KDM4E (0.47) | KDM4EGPR3F12PLAUNCF1 | |
| SCHEMBL22758297 | 0.69 | NCF1 (0.44) | KDM4EGPR3ACHEBCHENCF1 | |
| SCHEMBL11331611 | 0.68 | KDM4E (0.53) | KDM4EGPR3F12PLAUNCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2896613-B1 | SULFONAMIDE COMPOUND | MITSUBISHI TANABE PHARMA CORP (JP) | 2018-03-21 | — | — | EP | disclosed |
| EP-2896613-B1 | SULFONAMIDE COMPOUND | MITSUBISHI TANABE PHARMA CORP (JP) | 2018-03-21 | — | — | EP | disclosed |
| US-9540360-B2 | Sulfonamide compounds having TRPM8 antagonistic activity | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2017-01-10 | — | — | US | disclosed |
| US-9540360-B2 | Sulfonamide compounds having TRPM8 antagonistic activity | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2017-01-10 | — | — | US | disclosed |
| US-9540360-B2 | Sulfonamide compounds having TRPM8 antagonistic activity | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2017-01-10 | — | — | US | disclosed |
| US-9487488-B2 | Sulfonamide compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2016-11-08 | — | — | US | disclosed |
| US-9487488-B2 | Sulfonamide compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2016-11-08 | — | — | US | disclosed |
| US-9487488-B2 | Sulfonamide compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2016-11-08 | — | — | US | disclosed |
| CN-103443080-B | There is the sulfonamide compounds of TRPM8 antagonistic activity | 田边三菱制药株式会社 | 2016-10-12 | — | — | CN | disclosed |
| EP-2686302-B1 | SULFONAMIDE COMPOUNDS HAVING TRPM8 ANTAGONISTIC ACTIVITY | MITSUBISHI TANABE PHARMA CORP (JP) | 2016-08-10 | — | — | EP | disclosed |
| EP-2896613-A1 | SULFONAMIDE COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2015-07-22 | — | — | EP | disclosed |
| EP-2896613-A1 | SULFONAMIDE COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2015-07-22 | — | — | EP | disclosed |
| US-8987445-B2 | Sulfonamide compounds having TRPM8 antagonistic activity | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2015-03-24 | — | — | US | disclosed |
| US-8987445-B2 | Sulfonamide compounds having TRPM8 antagonistic activity | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2015-03-24 | — | — | US | disclosed |
| US-8987445-B2 | Sulfonamide compounds having TRPM8 antagonistic activity | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2015-03-24 | — | — | US | disclosed |
| WO-2014042238-A1 | SULFONAMIDE COMPOUND | 田辺三菱製薬株式会社 (JP) | 2014-03-20 | — | — | WO | disclosed |
| EP-2686302-A1 | SULFONAMIDE COMPOUNDS HAVING TRPM8 ANTAGONISTIC ACTIVITY | Mitsubishi Tanabe Pharma Corporation (JP) | 2014-01-22 | — | — | EP | disclosed |
| US-20140005393-A1 | SULFONAMIDE COMPOUNDS HAVING TRPM8 ANTAGONISTIC ACTIVITY | KALLYOPE, INC. | 2014-01-02 | — | — | US | disclosed |
| WO-2012124825-A1 | SULFONAMIDE COMPOUNDS HAVING TRPM8 ANTAGONISTIC ACTIVITY | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-09-20 | — | — | WO | disclosed |
| WO-2012124825-A1 | SULFONAMIDE COMPOUNDS HAVING TRPM8 ANTAGONISTIC ACTIVITY | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140005393-A1 | SULFONAMIDE COMPOUNDS HAVING TRPM8 ANTAGONISTIC ACTIVITY | TRPM8, TRPM7, TRPM2 | KDM4E 2496/4885GPR3 338/4885ACHE 2704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.