SCHEMBL1249201

SCHEMBL1249201

COc1ccc2c(c1)OCC1Oc3cc(OC)ccc3C21

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.54
▸ MAPK1 P28482 1/20 0.54
▸ TDP1 Q9NUW8 1/20 0.54
▸ ABCB1 P08183 3/20 0.50
▸ CYP3A4 P08684 2/20 0.45
▸ USP2 O75604 1/20 0.45
▸ DRD2 P14416 1/20 0.44
▸ DRD3 P35462 1/20 0.44
▸ CYP19A1 P11511 4/20 0.42
▸ MTNR1A P48039 1/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ ALDH1A1 P00352 1/20 0.40
▸ ACHE P22303 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pterocarpin SCHEMBL3231566 0.83 MAPT (0.85) MAPTMAPK1TDP1ABCB1CYP3A4
Homopterocarpin SCHEMBL31237481 0.77 MAPT (0.80) MAPTMAPK1TDP1ABCB1CYP3A4
SCHEMBL245538 0.77 MAPT (0.53) MAPTMAPK1TDP1ABCB1CYP3A4
SCHEMBL25893256 0.77 MAPT (0.53) MAPTMAPK1TDP1ABCB1CYP3A4
Homopterocarpin SCHEMBL12810250 0.77 MAPT (0.80) MAPTMAPK1TDP1ABCB1CYP3A4
SCHEMBL24103715 0.77 MAPT (0.53) MAPTMAPK1TDP1ABCB1CYP3A4
Homopterocarpin SCHEMBL12998414 0.77 MAPT (0.80) MAPTMAPK1TDP1ABCB1CYP3A4
Homopterocarpin SCHEMBL12810803 0.77 MAPT (0.80) MAPTMAPK1TDP1ABCB1CYP3A4
SCHEMBL38654119 0.76 MAPT (0.48) MAPTMAPK1TDP1CYP3A4DRD2
SCHEMBL25318575 0.76 CYP3A4 (0.54) MAPTMAPK1TDP1ABCB1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106987316-B Preparation method of pterocarpus santalinus essential oil with antibacterial activity 中国林业科学研究院林产化学工业研究所 2020-09-01 — — CN claimed
EP-2295031-B1 Use of pterocarpans as anti-cellulite agents SYMRISE AG (DE) 2018-01-10 — — EP claimed
EP-2295031-A2 Use of pterocarpans as anti-cellulite agents Symrise AG (DE) 2011-03-16 — — EP claimed
US-20110034486-A1 USE OF PTEROCARPANS AS ACTIVE ANTI-CELLULITE INGREDIENTS SYMRISE GMBH & CO., KG (DE) 2011-02-10 — — US claimed
CN-113116872-B Application of pterostilbene in anti-influenza A virus medicine 广东省第二人民医院(广东省卫生应急医院) 2022-06-24 — — CN disclosed
CN-114480057-A Nutritional herbal red sandalwood wine and preparation process thereof 缪海怡 2022-05-13 — — CN disclosed
CN-113171390-A Application of beautiful millettia root in preparation of medicine for treating hepatic fibrosis 杨增艳 2021-07-27 — — CN disclosed
WO-2021143037-A1 LACTOBACILLUS ACIDIPISCIS, FERMENTED SOYMILK, PREPARATION METHODS THEREFOR 河北农业大学 2021-07-22 — — WO disclosed
CN-113116872-A Application of pterostilbene in anti-influenza A virus medicine 广东省第二人民医院(广东省卫生应急医院) 2021-07-16 — — CN disclosed
CN-111821400-A Mongolian medicine for treating coronary heart disease and preparation method thereof 内蒙古天奇中蒙制药股份有限公司 2020-10-27 — — CN disclosed
US-20180042899-A1 Method of Treating Transplant Rejection and Autoimmune Diseases NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2018-02-15 — — US disclosed
EP-2295031-B1 Use of pterocarpans as anti-cellulite agents SYMRISE AG (DE) 2018-01-10 — — EP disclosed
US-20100305068-A1 COMPOUNDS AND METHODS FOR MODULATING PROTEIN TRAFFICKING FOLDRX PHARMACEUTICALS, INC. (US) 2010-12-02 — — US disclosed
US-20090269772-A1 SYSTEMS AND METHODS FOR IDENTIFYING COMBINATIONS OF COMPOUNDS OF THERAPEUTIC INTEREST THERASIS, INC. 2009-10-29 — — US disclosed
CN-101469296-A Novel toilet soap based on red sandalwood and nitric oxide local release technology BEIJING FUHUA ANDE BIOPHARMACE (CN) 2009-07-01 — — CN disclosed
US-20090143279-A1 Methods and compositions for treating metabolic disorders PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2009-06-04 — — US disclosed
EP-2054026-A1 COSMETIC ACTIVE INGREDIENT COMPOSITION COMPRISING SANDALWOOD EXTRACT Henkel AG & Co. KGaA (DE) 2009-05-06 — — EP disclosed
WO-2008156654-A2 CYTOSKELETON MODULATORS FOR TREATING METABOLIC DISORDERS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2008-12-24 — — WO disclosed
WO-2008025679-A1 COSMETIC ACTIVE INGREDIENT COMPOSITION COMPRISING SANDALWOOD EXTRACT HENKEL AG & CO. KGAA (DE) 2008-03-06 — — WO disclosed
US-5721371-A CATALYTIC CYCLIZATION A BENZOPYRANS WITH AN ORTHO-IODOPHENOLS IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 1998-02-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100305068-A1 COMPOUNDS AND METHODS FOR MODULATING PROTEIN TRAFFICKING GOLT1B, NPC1L1, NPC1 MAPT 459/4885MAPK1 2072/4885TDP1 2680/4885
US-20110034486-A1 USE OF PTEROCARPANS AS ACTIVE ANTI-CELLULITE INGREDIENTS FABP4, PLIN1, CPT1B MAPT 4747/4885MAPK1 767/4885TDP1 1491/4885
US-20090143279-A1 Methods and compositions for treating metabolic disorders PC, PCK2, CS MAPT 357/4885MAPK1 1515/4885TDP1 1461/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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