Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 12/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SHBG | P04278 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5724891 | 0.89 | SLC6A1 (0.43) | SLC6A1TAAR1HPGDGPR52 | |
| SCHEMBL6546899 | 0.80 | HPGD (0.45) | HPGDSHBGKDM4EALDH1A1GPR52 | |
| SCHEMBL5724863 | 0.72 | SLC6A1 (0.43) | SLC6A1HPGDGPR52 | |
| SCHEMBL5402022 | 0.70 | HPGD (0.51) | HPGDSHBGKDM4EALDH1A1 | |
| SCHEMBL6546961 | 0.70 | HPGD (0.47) | HPGDSHBGKDM4EALDH1A1 | |
| SCHEMBL1318497 | 0.68 | SLC6A1 (0.40) | SLC6A1GPR52 | |
| SCHEMBL7923183 | 0.68 | ERCC5 (0.39) | SLC6A1HPGDGPR52 | |
| SCHEMBL11348407 | 0.67 | SHBG (0.67) | HPGDSHBGKDM4EALDH1A1 | |
| SCHEMBL14415792 | 0.67 | MAOA (0.42) | SLC6A1HPGDALDH1A1 | |
| SCHEMBL19012291 | 0.66 | TAAR1 (0.41) | TAAR1HPGDKDM4EALDH1A1GPR52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2446903-A2 | Methods, compositions, and kits for treating pain and pruritis | President and Fellows of Harvard College (US) | 2012-05-02 | — | — | EP | disclosed |
| EP-2425858-A2 | Compositions for treating pain and pruritus | President and Fellows of Harvard College (US) | 2012-03-07 | — | — | EP | disclosed |