Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.55 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.55 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.49 |
| ▸ | NFATC1 | O95644 | 5/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 5/20 | 0.45 |
| ▸ | APP | P05067 | 3/20 | 0.43 |
| ▸ | SNCA | P37840 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.42 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12501062 | 0.80 | IKBKE (0.64) | PDPK1TGFBR1IKBKEDYRK1ANFATC1 | |
| SCHEMBL12501045 | 0.72 | TGFBR1 (1.00) | PDPK1TGFBR1IKBKEDYRK1ANFATC1 | |
| SCHEMBL14876913 | 0.69 | IKBKE (0.71) | PDPK1TGFBR1IKBKEDYRK1ANFATC1 | |
| SCHEMBL14857618 | 0.69 | APP (0.55) | APPSNCAKDM4C | |
| SCHEMBL20791838 | 0.69 | L3MBTL1 (0.56) | APPSNCA | |
| SCHEMBL26696137 | 0.68 | DYRK1A (0.80) | PDPK1TGFBR1IKBKEDYRK1ANFATC1 | |
| SCHEMBL13204316 | 0.67 | SIRT2 (0.58) | GSK3BAPPSNCACDK2CDK1 | |
| SCHEMBL28501215 | 0.67 | KDM4E (0.50) | DYRK1ANFATC1SIRT2 | |
| SCHEMBL20791839 | 0.67 | APP (0.53) | APPSNCA | |
| SCHEMBL28505106 | 0.66 | HTR7 (0.71) | SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3133074-A2 | 7-AZAINDOLE DERIVATIVES | Merck Patent GmbH (DE) | 2017-02-22 | — | — | EP | claimed |
| EP-2746281-A2 | 7-azaindole derivatives | Merck Patent GmbH (DE) | 2014-06-25 | — | — | EP | claimed |
| CN-103502247-A | 7-azaindole derivatives | MERCK PATENT GMBH | 2014-01-08 | — | — | CN | claimed |
| EP-3133074-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-12-09 | — | — | EP | disclosed |
| EP-3133074-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-12-09 | — | — | EP | disclosed |
| US-9725446-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2017-08-08 | — | — | US | disclosed |
| US-9725446-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2017-08-08 | — | — | US | disclosed |
| EP-3133074-A2 | 7-AZAINDOLE DERIVATIVES | Merck Patent GmbH (DE) | 2017-02-22 | — | — | EP | disclosed |
| EP-3133074-A2 | 7-AZAINDOLE DERIVATIVES | Merck Patent GmbH (DE) | 2017-02-22 | — | — | EP | disclosed |
| EP-2670748-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-09-28 | — | — | EP | disclosed |
| EP-2670748-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-09-28 | — | — | EP | disclosed |
| US-20150152104-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-04 | — | — | US | disclosed |
| US-8981101-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2015-03-17 | — | — | US | disclosed |
| US-8981101-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2015-03-17 | — | — | US | disclosed |
| EP-2746281-A2 | 7-azaindole derivatives | Merck Patent GmbH (DE) | 2014-06-25 | — | — | EP | disclosed |
| EP-2746281-A2 | 7-azaindole derivatives | Merck Patent GmbH (DE) | 2014-06-25 | — | — | EP | disclosed |
| CN-103502247-A | 7-azaindole derivatives | MERCK PATENT GMBH | 2014-01-08 | — | — | CN | disclosed |
| EP-2670748-A2 | 7-AZAINDOLE DERIVATIVES | Merck Patent GmbH (DE) | 2013-12-11 | — | — | EP | disclosed |
| US-20130310391-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-11-21 | — | — | US | disclosed |
| WO-2012104007-A2 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310391-A1 | 7-AZAINDOLE DERIVATIVES | PDK1, PDK2, PDK3 | PDPK1 12/4885TGFBR1 3500/4885IKBKE 1071/4885 |
| US-20150152104-A1 | 7-AZAINDOLE DERIVATIVES | PDK1, PDK2, PDK3 | PDPK1 12/4885TGFBR1 3500/4885IKBKE 1071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.