Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24627424 | 0.84 | ALDH1A1 (0.56) | NPC1USP2ALOX15TSHRMAPK1 | |
| SCHEMBL5147840 | 0.83 | USP2 (0.67) | NPC1USP2ALOX15TSHRMAPK1 | |
| SCHEMBL24627827 | 0.81 | L3MBTL1 (0.70) | NPC1USP2ALOX15TSHRMAPK1 | |
| SCHEMBL21595955 | 0.80 | NPC1 (0.73) | NPC1USP2ALOX15TSHRMAPK1 | |
| SCHEMBL12502459 | 0.80 | NPC1 (0.68) | NPC1USP2ALOX15TSHRMAPK1 | |
| SCHEMBL12502477 | 0.80 | PARP10 (0.65) | NPC1USP2ALOX15TSHRMAPK1 | |
| SCHEMBL10932269 | 0.79 | ALDH1A1 (0.61) | TSHRSMN1; SMN2HPGDALDH1A1TBXAS1 | |
| SCHEMBL21596070 | 0.79 | MTNR1A (0.75) | NPC1USP2ALOX15TSHRMAPK1 | |
| SCHEMBL578734 | 0.79 | ALDH1A1 (0.61) | SMN1; SMN2HPGDALDH1A1TBXAS1MAOB | |
| SCHEMBL12502158 | 0.79 | NPC1 (0.70) | NPC1USP2ALOX15TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670734-A1 | NOVEL ETHER LINKED COMPOUNDS AND IMPROVED TREATMENTS FOR CARDIAC AND CARDIOVASCULAR DISEASE | UNIVERSITY OF NOTTINGHAM (GB) | 2013-12-11 | — | — | EP | disclosed |
| WO-2012104659-A1 | NOVEL ETHER LINKED COMPOUNDS AND IMPROVED TREATMENTS FOR CARDIAC AND CARDIOVASCULAR DISEASE | UNIVERSITY OF NOTTINGHAM (GB) | 2012-08-09 | — | — | WO | disclosed |