Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 9/20 | 0.41 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 14/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 14/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 8/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1250723 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2CHRNA3CHRNA1CHRNA7CHRNB2 | |
| SCHEMBL6852000 | 0.79 | SMN1; SMN2 (0.63) | SMN1; SMN2CHRNA3CHRNA1CHRNA7CHRNB2 | |
| SCHEMBL6852003 | 0.79 | SMN1; SMN2 (0.63) | SMN1; SMN2CHRNA3CHRNA1CHRNA7CHRNB2 | |
| SCHEMBL28393463 | 0.79 | ADRB1 (0.41) | SMN1; SMN2CHRNA3CHRNA1CHRNA7CYP3A4 | |
| SCHEMBL28393468 | 0.77 | SMN1; SMN2 (0.39) | SMN1; SMN2CHRNA3CHRNA1CHRNA7CYP1A2 | |
| SCHEMBL9217916 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2CHRNA3CHRNA1CHRNA7CHRNB2 | |
| SCHEMBL9217910 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2CHRNA3CHRNA1CHRNA7CHRNB2 | |
| SCHEMBL9207922 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2CHRNA3CHRNA1CHRNA7 | |
| SCHEMBL28400518 | 0.74 | SMN1; SMN2 (0.41) | SMN1; SMN2CHRNA3CHRNA1CHRNA7CYP1A2 | |
| SCHEMBL9219085 | 0.74 | CHRNB2 (0.43) | SMN1; SMN2CHRNA3CHRNA1CHRNA7CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2281812-B1 | NITROGENOUS HETEROCYCLIC COMPOUND WITH INSECTICIDAL ACTIVITY AND ITS PREPARATION AND USE | UNIV EAST CHINA SCIENCE & TECH (CN) | 2014-01-22 | — | — | EP | disclosed |
| US-8232407-B2 | Nitrogenous heterocyclic compounds with insecticidal activity, and the preparation and use thereof | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2012-07-31 | — | — | US | disclosed |
| EP-2281812-A1 | NITROGENOUS HETEROCYCLIC COMPOUND WITH INSECTICIDAL ACTIVITY AND ITS PREPARATION AND USE | East China University of Science and Technology (CN) | 2011-02-09 | — | — | EP | disclosed |
| US-20100298346-A1 | NITROGENOUS HETEROCYCLIC COMPOUNDS WITH INSECTICIDAL ACTIVITY, AND THE PREPARATION AND USE THEREOF | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298346-A1 | NITROGENOUS HETEROCYCLIC COMPOUNDS WITH INSECTICIDAL ACTIVITY, AND THE PREPARATION AND USE THEREOF | NIT2, NOS2, NOS3 | SMN1; SMN2 3997/4885CHRNA3 427/4885CHRNA1 769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.