Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | SORD | Q00796 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200378 | 0.83 | LMNA (0.52) | LMNAL3MBTL1MAPTACHESORD | |
| SCHEMBL15071226 | 0.80 | LMNA (0.48) | LMNAL3MBTL1MAPTSORDKDM4E | |
| SCHEMBL15071182 | 0.80 | L3MBTL1 (0.46) | LMNAL3MBTL1MAPTACHEHTT | |
| SCHEMBL12516747 | 0.80 | HRH3 (0.52) | LMNAL3MBTL1MAPTSORDKDM4E | |
| SCHEMBL14206444 | 0.77 | MAP4K4 (0.41) | HRH3 | |
| SCHEMBL12515928 | 0.77 | MAPT (0.50) | LMNAL3MBTL1MAPTKDM4EGAA | |
| SCHEMBL12516966 | 0.76 | ALDH1A1 (0.41) | LMNAL3MBTL1KDM4EGAAALDH1A1 | |
| SCHEMBL25870823 | 0.76 | GAA (0.56) | LMNAL3MBTL1MAPTKDM4EGAA | |
| SCHEMBL15071187 | 0.76 | VCP (0.45) | LMNAL3MBTL1MAPTKDM4EGAA | |
| SCHEMBL12516535 | 0.76 | CYP1A2 (0.49) | LMNAL3MBTL1KDM4EMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130164259-A1 | 1,4-SUBSTITUTED PIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION | 2013-06-27 | — | — | US | disclosed |
| US-20130164259-A1 | 1,4-SUBSTITUTED PIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION | 2013-06-27 | — | — | US | disclosed |
| WO-2011087738-A2 | 1,4-SUBSTITUTED PIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130164259-A1 | 1,4-SUBSTITUTED PIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF | ZC3HAV1, BAZ2A, HAVCR2 | LMNA 2722/4885L3MBTL1 1441/4885MAPT 2898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.