Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNPAT | O15228 | 1/20 | 0.55 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.54 |
| ▸ | CTSL | P07711 | 3/20 | 0.53 |
| ▸ | CTSS | P25774 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ACE | P12821 | 4/20 | 0.52 |
| ▸ | MME | P08473 | 3/20 | 0.52 |
| ▸ | CPA1 | P15085 | 2/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.51 |
| ▸ | CBX4 | O00257 | 1/20 | 0.50 |
| ▸ | CBX7 | O95931 | 1/20 | 0.50 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.50 |
| ▸ | CBX8 | Q9HC52 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30799863 | 0.88 | GNPAT (0.58) | GNPATACEMMECPA1ACE2 | |
| SCHEMBL10119206 | 0.87 | CTSL (0.61) | GNPATPSMB5CTSLCTSSCTSK | |
| SCHEMBL12518333 | 0.87 | CDYL2 (0.49) | PSMB5CTSLCTSSCTSKL3MBTL1 | |
| SCHEMBL10118861 | 0.86 | CTSK (0.57) | PSMB5CTSLCTSSCTSKL3MBTL1 | |
| SCHEMBL10118860 | 0.86 | CTSK (0.57) | PSMB5CTSLCTSSCTSKL3MBTL1 | |
| SCHEMBL10118863 | 0.86 | CTSK (0.57) | PSMB5CTSLCTSSCTSKL3MBTL1 | |
| SCHEMBL14297678 | 0.85 | CTSB (0.60) | PSMB5CTSLCTSSCTSKL3MBTL1 | |
| SCHEMBL3504191 | 0.85 | NPY4R (0.53) | GNPATPSMB5CTSLCTSSCTSK | |
| SCHEMBL6674259 | 0.84 | MME (0.51) | ACEMMECPA1ACE2CA2 | |
| SCHEMBL12518309 | 0.84 | CTSB (0.62) | PSMB5CTSLCTSSL3MBTL1CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2526116-B1 | PYRUVAMIDE COMPOUNDS AS INHIBITORS OF DUST MITE GROUP 1 PEPTIDASE ALLERGEN | ST GEORGES HOSP MEDICAL SCHOOL (GB) | 2015-05-13 | — | — | EP | disclosed |
| US-8637453-B2 | Pyruvamide compounds as inhibitors of dust mite group 1 peptidase allergen and their use | ST GEORGE'S HOSPITAL MEDICAL SCHOOL (GB) | 2014-01-28 | — | — | US | disclosed |
| US-8541363-B2 | Pyruvamide compounds as inhibitors of dust mite group 1 peptidase allergen and their use | St George's Hosptial Medical School (GB) | 2013-09-24 | — | — | US | disclosed |
| US-20130217617-A1 | Pyruvamide Compounds as Inhibitors of Dust Mite Group 1 Peptidase Allergen and Their Use | THE UNIVERSITY OF MANCHESTER (GB) | 2013-08-22 | — | — | US | disclosed |
| US-20120322722-A1 | Pyruvamide Compounds as Inhibitors of Dust Mite Group 1 Peptidase Allergen and Their Use | THE UNIVERSITY OF MANCHESTER (GB) | 2012-12-20 | — | — | US | disclosed |
| WO-2011089396-A2 | PYRUVAMIDE COMPOUNDS AS INHIBITORS OF DUST MITE GROUP 1 PEPTIDASE ALLERGEN AND THEIR USE. | ST GEORGE'S HOSPITAL MEDICAL SCHOOL (GB) | 2011-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217617-A1 | Pyruvamide Compounds as Inhibitors of Dust Mite Group 1 Peptidase Allergen and Their Use | PREP, DPEP1, DPP8 | GNPAT 1672/4885PSMB5 484/4885CTSL 535/4885 |
| US-20120322722-A1 | Pyruvamide Compounds as Inhibitors of Dust Mite Group 1 Peptidase Allergen and Their Use | PREP, DPEP1, PEPD | GNPAT 2095/4885PSMB5 408/4885CTSL 669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.