Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | POLA1 | P09884 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.36 |
| ▸ | CDC25A | P30304 | 2/20 | 0.35 |
| ▸ | CDC25B | P30305 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL267926 | 0.81 | NR1H3 (0.58) | NR1H3CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL14286750 | 0.81 | NR1H3 (0.58) | NR1H3CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL12450206 | 0.81 | NR1H3 (0.58) | NR1H3CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL280372 | 0.80 | PTGS1 (0.32) | NR1H3CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL280289 | 0.77 | KARS1 (0.39) | NR1H3CYP3A4KARS1MAPTPTGS1 | |
| SCHEMBL12887757 | 0.77 | NR1H3 (0.54) | NR1H3CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL280071 | 0.77 | NR1H3 (0.54) | NR1H3CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL280149 | 0.77 | NR1H3 (0.31) | NR1H3 | |
| SCHEMBL280188 | 0.76 | SOD1 (0.47) | NR1H3CYP3A4ALOX15USP2MAPT | |
| SCHEMBL280154 | 0.76 | SOD1 (0.47) | NR1H3CYP3A4ALOX15USP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238634-A1 | INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-ALPHA MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS | NEREUS PHARMACEUTICALS, INC. (US) | 2012-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238634-A1 | INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-ALPHA MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS | IL1A, IL1B, TNF | NR1H3 3538/4885CYP3A4 2799/4885CYP2C9 2777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.