Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 9/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PROKR2 | Q8NFJ6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5175180 | 0.90 | PROKR1 (0.42) | PROKR1POLBPROKR2 | |
| SCHEMBL10267964 | 0.87 | RGS4 (0.42) | PROKR1TP53PROKR2 | |
| SCHEMBL325745 | 0.85 | DYRK1A (0.42) | POLBGAATP53 | |
| SCHEMBL326810 | 0.83 | PROKR2 (0.45) | PROKR1PROKR2 | |
| SCHEMBL14900197 | 0.79 | RGS4 (0.48) | PROKR1PROKR2 | |
| SCHEMBL325145 | 0.78 | ALDH1A1 (0.49) | POLBGAA | |
| SCHEMBL8577834 | 0.77 | POLB (0.63) | POLB | |
| SCHEMBL14463668 | 0.76 | ALDH1A1 (0.49) | PROKR1POLBGAAPROKR2 | |
| SCHEMBL8520540 | 0.74 | MTNR1A (0.44) | — | |
| SCHEMBL1752475 | 0.73 | PROKR1 (0.48) | PROKR1GAATP53PROKR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968710-B2 | Gastrointestinal disorders;inflammatory bowel disorders; gastroesophageal reflux; constipation | JANSSEN PHARMACEUTICA NV (BE) | 2011-06-28 | — | — | US | disclosed |
| US-7968710-B2 | Gastrointestinal disorders;inflammatory bowel disorders; gastroesophageal reflux; constipation | JANSSEN PHARMACEUTICA NV (BE) | 2011-06-28 | — | — | US | disclosed |