Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11536910 | 0.84 | ALDH1A1 (1.00) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26313603 | 0.82 | ALDH1A1 (0.97) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2981180 | 0.82 | ALDH1A1 (0.97) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12550301 | 0.81 | HSD11B1 (1.00) | ALDH1A1MAPTHSD11B1LMNAKMT2A | |
| SCHEMBL17290508 | 0.80 | ALDH1A1 (0.69) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12550071 | 0.80 | HSD11B1 (0.83) | ALDH1A1MAPTHSD11B1LMNATSHR | |
| SCHEMBL4130602 | 0.77 | ALDH1A1 (0.60) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16013324 | 0.77 | HSD11B1 (0.62) | ALDH1A1HSD11B1LMNATSHRGLA | |
| SCHEMBL20722196 | 0.76 | ALDH1A1 (0.62) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5560091 | 0.75 | LMNA (1.00) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110129542-A1 | SUBSTITUTED AZEPINE- AND DIAZEPINE-SULFONAMIDES USEFUL TO INHIBIT 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | SCHERING CORPORATION | 2011-06-02 | — | — | US | disclosed |
| US-20110129542-A1 | SUBSTITUTED AZEPINE- AND DIAZEPINE-SULFONAMIDES USEFUL TO INHIBIT 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | SCHERING CORPORATION | 2011-06-02 | — | — | US | disclosed |
| WO-2009023664-A2 | SUBSTITUTED AZEPINE- AND DIAZEPINE-SULFONAMIDES USEFUL TO INHIBIT 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | SCHERING CORPORATION (US) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110129542-A1 | SUBSTITUTED AZEPINE- AND DIAZEPINE-SULFONAMIDES USEFUL TO INHIBIT 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | HSD11B1, HSD17B1, HSD3B1 | ALDH1A1 45/4885MAPT 4599/4885NPC1 833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.