Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 1.00 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.72 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.72 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.72 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.72 |
| ▸ | RAF1 | P04049 | 4/20 | 0.72 |
| ▸ | BRAF | P15056 | 2/20 | 0.72 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | TP53 | P04637 | 3/20 | 0.63 |
| ▸ | GCGR | P47871 | 2/20 | 0.63 |
| ▸ | NOX1 | Q9Y5S8 | 3/20 | 0.61 |
| ▸ | MGAM | O43451 | 1/20 | 0.57 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1068914 | 0.97 | PTPN1 (0.94) | PTPN1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6469184 | 0.90 | MAPK14 (0.90) | PTPN1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5624801 | 0.88 | MAPK14 (0.81) | PTPN1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL12561713 | 0.86 | MAPK13 (0.83) | PTPN1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL31255400 | 0.86 | MAPK13 (0.83) | PTPN1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL14514175 | 0.85 | PTPN1 (0.73) | PTPN1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9619859 | 0.84 | MAPK13 (0.85) | PTPN1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL15401173 | 0.84 | MAPK13 (0.85) | PTPN1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL252964 | 0.84 | MAPK13 (0.85) | PTPN1MAPK13MAPK12MAPK11MAPK14 | |
| Phloroglucinol SCHEMBL28606657 | 0.84 | PTPN1 (0.72) | PTPN1MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150374669-A1 | ARYL IMIDAZOLES AND THEIR USE AS ANTI-CANCER AGENTS | LORUS THERAPEUTICS INC. (CA) | 2015-12-31 | — | — | US | disclosed |
| US-20150374669-A1 | ARYL IMIDAZOLES AND THEIR USE AS ANTI-CANCER AGENTS | LORUS THERAPEUTICS INC. (CA) | 2015-12-31 | — | — | US | disclosed |
| US-8987305-B2 | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents | APTOSE BIOSCIENCES INC. (CA) | 2015-03-24 | — | — | US | disclosed |
| US-8987305-B2 | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents | APTOSE BIOSCIENCES INC. (CA) | 2015-03-24 | — | — | US | disclosed |
| US-8969372-B2 | Aryl imidazoles and their use as anti-cancer agents | Aptose Boisciences Inc. (CA) | 2015-03-03 | — | — | US | disclosed |
| US-8969372-B2 | Aryl imidazoles and their use as anti-cancer agents | Aptose Boisciences Inc. (CA) | 2015-03-03 | — | — | US | disclosed |
| US-20130177632-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | APTOSE BIOSCIENCES INC. (CA) | 2013-07-11 | — | — | US | disclosed |
| US-20130177632-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | APTOSE BIOSCIENCES INC. (CA) | 2013-07-11 | — | — | US | disclosed |
| US-8394815-B2 | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents | LORUS THERAPEUTICS INC. (CA) | 2013-03-12 | — | — | US | disclosed |
| US-8394815-B2 | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents | LORUS THERAPEUTICS INC. (CA) | 2013-03-12 | — | — | US | disclosed |
| US-20110152337-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | LORUS THERAPEUTICS INC. (CA) | 2011-06-23 | — | — | US | disclosed |
| US-7884120-B2 | microbiocides such as 2-(2-methyl-1H-indol-3-yl)-3a,11b-dihydro-1H-phenanthro[9,10-d]imidazole; bactericides; fungicides | LORUS THERAPEUTICS INC. (CA) | 2011-02-08 | — | — | US | disclosed |
| US-7884120-B2 | microbiocides such as 2-(2-methyl-1H-indol-3-yl)-3a,11b-dihydro-1H-phenanthro[9,10-d]imidazole; bactericides; fungicides | LORUS THERAPEUTICS INC. (CA) | 2011-02-08 | — | — | US | disclosed |
| US-20080262015-A9 | Aryl imidazoles and their use as anti-cancer agents | LORUS THERAPEUTICS INC. (CA) | 2008-10-23 | — | — | US | disclosed |
| US-20080262015-A9 | Aryl imidazoles and their use as anti-cancer agents | LORUS THERAPEUTICS INC. (CA) | 2008-10-23 | — | — | US | disclosed |
| WO-2005047266-A9 | ARYL IMIDAZOLES AND THEIR USE AS ANTI-CANCER AGENTS | LORUS THERAPEUTICS INC (CA) | 2008-04-17 | — | — | WO | disclosed |
| US-20070123553-A1 | Aryl imidazoles and their use as anti-cancer agents | LORUS THERAPEUTICS INC. (CA) | 2007-05-31 | — | — | US | disclosed |
| US-20070123553-A1 | Aryl imidazoles and their use as anti-cancer agents | LORUS THERAPEUTICS INC. (CA) | 2007-05-31 | — | — | US | disclosed |
| US-20070105929-A1 | 2, 4, 5 - Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents | APTOSE BIOSCIENCES INC. (CA) | 2007-05-10 | — | — | US | disclosed |
| US-20070105929-A1 | 2, 4, 5 - Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents | APTOSE BIOSCIENCES INC. (CA) | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130177632-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | IDO2, ERG28, IL4 | PTPN1 1231/4885MAPK13 3668/4885MAPK12 3161/4885 |
| US-20110152337-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | IDO2, ERG28, IL4 | PTPN1 1231/4885MAPK13 3668/4885MAPK12 3161/4885 |
| US-20070123553-A1 | Aryl imidazoles and their use as anti-cancer agents | AHR, AADAC, CBR3 | PTPN1 879/4885MAPK13 4059/4885MAPK12 3204/4885 |
| US-20150374669-A1 | ARYL IMIDAZOLES AND THEIR USE AS ANTI-CANCER AGENTS | AHR, CBR3, AADAC | PTPN1 906/4885MAPK13 4087/4885MAPK12 3446/4885 |
| US-20070105929-A1 | 2, 4, 5 - Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents | IDO2, ERG28, IL4 | PTPN1 1231/4885MAPK13 3668/4885MAPK12 3161/4885 |
| US-20080262015-A9 | Aryl imidazoles and their use as anti-cancer agents | AHR, AADAC, CBR3 | PTPN1 879/4885MAPK13 4059/4885MAPK12 3204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.